1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. H3B-120

H3B-120 

Cat. No.: HY-136128 Purity: 98.45%
Handling Instructions

H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity.

For research use only. We do not sell to patients.

H3B-120 Chemical Structure

H3B-120 Chemical Structure

CAS No. : 2194903-42-7

Size Price Stock Quantity
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity[1].

IC50 & Target

IC50: 1.5 μM (CPS1)[1]
Ki: 1.4 μM (CPS1)[1]

In Vitro

H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase)[1].
H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains[1].
H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays[1].
The half-life of H3B-120 is only 40 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

372.48

Formula

C₁₉H₂₄N₄O₂S

CAS No.

2194903-42-7

SMILES

O=C(N1CCC(C(NC2=NC(C)=CS2)=O)CC1)N(C)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (167.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6847 mL 13.4235 mL 26.8471 mL
5 mM 0.5369 mL 2.6847 mL 5.3694 mL
10 mM 0.2685 mL 1.3424 mL 2.6847 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.45%

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Keywords:

H3B-120Potassium ChannelKcsAcarbamoylphosphatesynthetase1CPS1anti-cancerInhibitorinhibitorinhibit

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Product Name:
H3B-120
Cat. No.:
HY-136128
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