Ern1 - endoplasmic reticulum to nucleus signaling 1 Gene
Also Known as RGD1559716
Species: Rattus norvegicus
About Ern1
This gene has 5 transcripts (splice variants), 133 orthologues, 1 paralogue and is associated with 15 phenotypes. Biased expression in Adrenal (RPKM 96.2), Liver (RPKM 78.3) and 9 other tissues.
Summary
Enables HSP90 protein binding activity. Involved in cellular response to glucose stimulus; cellular response to hydrogen peroxide; and cellular response to manganese ion. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and IRE1-TRAF2-ASK1 complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]
Ern1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001191926.1 | NP_001178855.1 | serine/threonine-protein kinase/endoribonuclease IRE1 |
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Ern1 Protein Structure
Luminal_IRE1: cd09769 (36 - 304)
STKc_IRE1: cd13982 (572 - 837)
RNase_Ire1: cd10422 (840 - 965)
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- 982 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein kinase/endoribonuclease IRE1 |
|