Ern1 - endoplasmic reticulum to nucleus signaling 1 Gene

Rattus norvegicus

Also known as RGD1559716

Gene ID: 498013 | Gene type: protein coding

About Ern1

Primary_assembly 10: 91,330,654-91,421,029 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 133 orthologues, 1 paralogue and is associated with 15 phenotypes. Biased expression in Adrenal (RPKM 96.2), Liver (RPKM 78.3) and 9 other tissues.

Summary

Enables HSP90 protein binding activity. Involved in cellular response to glucose stimulus; cellular response to hydrogen peroxide; and cellular response to manganese ion. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and IRE1-TRAF2-ASK1 complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]

Ern1 Products(1)

mRNA	Protein	Name
NM_001191926.1	NP_001178855.1	serine/threonine-protein kinase/endoribonuclease IRE1

Ern1 Protein Structure

Luminal_IRE1

STKc_IRE1

RNase_Ire1

0
200
400
600
800
982 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase/endoribonuclease IRE1

endoplasmic reticulum (ER) to nucleus signalling 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136735	IRE1α kinase-IN-1	Inhibitor	99.44%	Unkown
HY-RS04507	ERN1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04508	Ern1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04509	Ern1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ern1	NCBI	NCBI:2081

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