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Ednrb - endothelin receptor type B Gene

Also Known as Etb; Ednra

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 50672

About Ednrb

Primary_assembly 15: 80,643,043-80,672,115 reverse strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 263 orthologues, 14 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 419.4), Brain (RPKM 227.) and 7 other tissues.

Summary

Enables Endothelin Receptor activity and type 1 Angiotensin Receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of penile erection; and positive regulation of renal sodium excretion. Located in membrane raft; nuclear membrane; and plasma membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome type 4A; Waardenburg's syndrome; and asthma. Orthologous to human EDNRB (Endothelin Receptor type B). [provided by Alliance of Genome Resources, Apr 2022]

Ednrb Products (1)

mRNA	Protein	Name
NM_017333.1	NP_059029.1	endothelin receptor type B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endothelin receptor activity	IDA IDA: Inferred from direct assay	2175397	RGD
enables type 1 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	16014039	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17585504	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18091567	RGD
involved in epithelial fluid transport	IMP IMP: Inferred from mutant phenotype	18948426	RGD
involved in melanocyte differentiation	IDA IDA: Inferred from direct assay	11709437	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18683040	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15245872	RGD
involved in pigmentation	IMP IMP: Inferred from mutant phenotype	8570650	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18683040	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	2175397	RGD
involved in positive regulation of penile erection	IMP IMP: Inferred from mutant phenotype	19884966	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	16014039	RGD
involved in positive regulation of urine volume	IMP IMP: Inferred from mutant phenotype	18305094	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16763077	RGD
involved in regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12538737	RGD
involved in regulation of fever generation	IMP IMP: Inferred from mutant phenotype	16123229	RGD
involved in response to endothelin	IMP IMP: Inferred from mutant phenotype	10749572	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	20888431	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19851775	RGD
involved in response to pain	IMP IMP: Inferred from mutant phenotype	12847519	RGD
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	14678950	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	14678950	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear membrane	IDA IDA: Inferred from direct assay	12756260	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ednrb Protein Structure

7tmA_ET-BR

0
100
200
300
400
442 a.a.

Protein Preferred Names	Protein Names
endothelin receptor type B	ET-B ET-BR endothelin B receptor endothelin receptor non-selective type

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04169	EDNRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04170	Ednrb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04171	Ednrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ednrb	NCBI	NCBI:1910