Ednrb - endothelin receptor type B Gene

Rattus norvegicus

Also known as Etb; Ednra

Gene ID: 50672 | Gene type: protein coding

About Ednrb

Primary_assembly 15: 80,643,043-80,672,115 reverse strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 263 orthologues, 14 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 419.4), Brain (RPKM 227.) and 7 other tissues.

Summary

Enables Endothelin Receptor activity and type 1 Angiotensin Receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of penile erection; and positive regulation of renal sodium excretion. Located in membrane raft; nuclear membrane; and plasma membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome type 4A; Waardenburg's syndrome; and asthma. Orthologous to human EDNRB (Endothelin Receptor type B). [provided by Alliance of Genome Resources, Apr 2022]

Ednrb Products(1)

mRNA	Protein	Name
NM_017333.1	NP_059029.1	endothelin receptor type B precursor

Ednrb Protein Structure

7tmA_ET-BR

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

endothelin receptor type B

ET-B	ET-BR
endothelin B receptor	endothelin receptor non-selective type

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS04169	EDNRB Human Pre-designed siRNA Set A	/	Unkown
HY-RS04170	Ednrb Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS04171	Ednrb Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ednrb	NCBI	NCBI:1910

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