Slc6a8 - solute carrier family 6 member 8 Gene

Also Known as CRT; CT1; CHT1; CHOT1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50690

Summary

Enables choline transmembrane transporter activity and creatine:sodium symporter activity. Involved in creatine transmembrane transport and embryonic brain development. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a8 Products (1)

mRNA Protein Name
NM_017348.3 NP_059044.1 sodium- and chloride-dependent creatine transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables choline transmembrane transporter activity IDA
IDA: Inferred from direct assay
1633856 RGD
enables creatine transmembrane transporter activity IDA
IDA: Inferred from direct assay
8297374 RGD
enables creatine:sodium symporter activity IDA
IDA: Inferred from direct assay
8297374 RGD
Biological Process GO Annotation Evidence References Source
involved in creatine transmembrane transport IDA
IDA: Inferred from direct assay
8297374 RGD
involved in embryonic brain development IEP
IEP: Inferred from expression pattern
15918910 RGD
involved in protein catabolic process EXP
EXP: Inferred from Experiment
20731764 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
20731764 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12433955 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20731764 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
32115505 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
20731764 RGD
is active in synapse EXP
EXP: Inferred from Experiment
20731764 RGD
is active in synapse IDA
IDA: Inferred from direct assay
20731764 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent creatine transporter 1

  • choline transporter

  • creatine transporter 1

  • solute carrier family 6 (neurotransmitter transporter), member 8

  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W015828 Ompenaclid Inducer 99.94% Phase 3

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169294 SLC6A8 corrector 1 Inhibitor 99.94% Unkown
HY-RS13319 SLC6A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158161 JN-170 Inhibitor / Unkown
HY-169295 RAP 1 / Unkown
HY-181753 INSP-0154 / Unkown
HY-W695425 Creatine transporter-IN-1 Inhibitor / Unkown
HY-RS17671 Slc6a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24132 Slc6a8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a8 NCBI NCBI:6535