Fbxw7 - F-box and WD-40 domain protein 7 Gene

Also Known as AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50754

Summary

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in cellular protein catabolic process. Acts upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; genitourinary system; and skeletal muscle tissue. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw7 Products (3)

mRNA Protein Name
NM_001177773.1 NP_001171244.1 F-box/WD repeat-containing protein 7 isoform 1
NM_001177774.1 NP_001171245.1 F-box/WD repeat-containing protein 7 isoform 1
NM_080428.3 NP_536353.2 F-box/WD repeat-containing protein 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11425854 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
11425854 MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
21953459 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
21503901 MGI
involved in negative regulation of osteoclast development IMP
IMP: Inferred from mutant phenotype
29149593 MGI
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23858059 MGI
involved in positive regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
23858059 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
27238018 MGI
involved in regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
23507969 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
27238018 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
21503901 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11735228 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11735228 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
23858059 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
11735228 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20208556 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20208556 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 7

  • F-box and WD-40 domain protein 7, archipelago homolog

  • F-box and WD-40 domain-containing protein 7

  • F-box-WD40 repeat protein 6

  • f-box only protein 30

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04818 FBXW7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173082 10-SLF Degrader / Unkown
HY-RS17548 Fbxw7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24007 Fbxw7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxw7 NCBI NCBI:55294