SPOCK3 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 Gene

Also Known as TES-3; TICN3; HSAJ1454

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50859

About SPOCK3

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:166,733,384-167,234,945 (from NCBI)

This gene has 26 transcripts (splice variants), 190 orthologues and 3 paralogues. Biased expression in brain (RPKM 28.5), prostate (RPKM 28.2) and 2 other tissues.

Summary

This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type Matrix Metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

SPOCK3 Products (9)

mRNA Protein Name
NM_001040159.2 NP_001035249.1 testican-3 isoform 1 precursor
NM_001204352.2 NP_001191281.1 testican-3 isoform 3
NM_001204353.1 NP_001191282.1 testican-3 isoform 4
NM_001204354.2 NP_001191283.1 testican-3 isoform 5
NM_001204355.2 NP_001191284.1 testican-3 isoform 6
NM_001204356.2 NP_001191285.1 testican-3 isoform 7 precursor
NM_001204358.2 NP_001191287.1 testican-3 isoform 9 precursor
NM_001251967.2 NP_001238896.1 testican-3 isoform 11 precursor
NM_016950.3 NP_058646.2 testican-3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
11751414 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
11751414 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
11751414 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
11751414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOCK3 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (142 - 183)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (199 - 308)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (317 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

testican-3

  • SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13697 SPOCK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21199 Spock3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27715 Spock3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPOCK3 RGD RGD:1305672
Canis familiaris SPOCK3 VGNC VGNC:54224
Felis catus SPOCK3 VGNC VGNC:107469
Mus musculus SPOCK3 MGD MGI:1920152
Macaca mulatta SPOCK3 VGNC VGNC:100272
Others SPOCK3 NCBI