Chek2 - checkpoint kinase 2 Gene

Also Known as CHK2; Cds1; Rad53; HUCDS1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50883

About Chek2

Chromosome 5: 110,987,845-111,022,011 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 206 orthologues and is associated with 8 phenotypes. Broad expression in liver E14 (RPKM 9.9), liver E14.5 (RPKM 8.7) and 23 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within cellular response to gamma radiation; peptidyl-serine phosphorylation; and signal transduction by p53 class mediator. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Chek2 Products (2)

mRNA Protein Name
NM_001363308.1 NP_001350237.1 serine/threonine-protein kinase Chk2 isoform 2
NM_016681.4 NP_057890.1 serine/threonine-protein kinase Chk2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
10710310 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
10710310 MGI
acts upstream of or within cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
10710310 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
10710310 MGI
acts upstream of or within mitotic G2 phase IMP
IMP: Inferred from mutant phenotype
10710310 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
10710310 MGI
acts upstream of or within response to gamma radiation IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within signal transduction in response to DNA damage IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
18614044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek2 Protein Structure

FHA_CHK2

FHA_CHK2: cd22666 (96 - 207)

STKc_Chk2

STKc_Chk2: cd14084 (216 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 546 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk2

  • CHK2 checkpoint homolog

  • Cds1 homolog

  • Rad53 homolog

Recombinant Chek2 Proteins

Cat. No. Product Name Accession Purity
HY-P75348 CHEK2 Protein, Mouse (sf9, His-GST) Q9Z265 (M1-L546) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-RS02619 CHEK2 Human Pre-designed siRNA Set A / Unkown
HY-RS02620 Chek2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02621 Chek2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek2 NCBI NCBI:11200