Mink1 - misshapen-like kinase 1 (zebrafish) Gene

Also Known as B55; MINK; Ysk2; Map4k6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50932

About Mink1

Chromosome 11: 70,453,707-70,505,309 forward strand.GRCm39:CM001004.3

This gene has 13 transcripts (splice variants), 204 orthologues, 35 paralogues and is associated with 19 phenotypes. Ubiquitous expression in cortex adult (RPKM 44.5), frontal lobe adult (RPKM 42.1) and 28 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in positive regulation of JNK cascade; positive regulation of p38MAPK cascade; and protein phosphorylation. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mink1 Products (7)

mRNA Protein Name
NM_001403557.1 NP_001390486.1 misshapen-like kinase 1 isoform 7
NM_001403556.1 NP_001390485.1 misshapen-like kinase 1 isoform 6
NM_001403555.1 NP_001390484.1 misshapen-like kinase 1 isoform 5
NM_001045959.2 NP_001039424.1 misshapen-like kinase 1 isoform 3
NM_016713.3 NP_057922.2 misshapen-like kinase 1 isoform 1
NM_001045964.2 NP_001039429.1 misshapen-like kinase 1 isoform 4
NM_176893.3 NP_795712.2 misshapen-like kinase 1 isoform 2

Mink1 Protein Structure

STKc_MAP4K4_6_N

STKc_MAP4K4_6_N: cd06636 (7 - 288)

CNH

CNH: smart00036 (981 - 1279)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1300 a.a.
Protein Preferred Names Protein Names

misshapen-like kinase 1

  • GCK family kinase MiNK

  • MAPK/ERK kinase kinase kinase 6

  • MEK kinase kinase 6

  • MEKKK 6

  • Misshapen/NIKs-related kinase

  • Yeast Sps1/Ste20-related kinase 2

  • misshapen/NIK-related kinase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17437A Mefloquine hydrochloride 99.98% Yes
HY-17437 Mefloquine 99.79% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111754 DMX-5804 Inhibitor 99.64% Unkown
HY-108591 L-364,373 Activator 99.65% Unkown
HY-RS08454 MINK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08455 Mink1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08456 Mink1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-178775 PI4K-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mink1 NCBI NCBI:50488