PDE11A - phosphodiesterase 11A Gene

Also Known as PPNAD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50940

About PDE11A

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:177,623,244-178,108,339 (from NCBI)

This gene has 12 transcripts (splice variants), 101 orthologues, 20 paralogues and is associated with 2 phenotypes. Biased expression in prostate (RPKM 3.1), fat (RPKM 1.5) and 11 other tissues.

Summary

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE11A Products (4)

mRNA	Protein	Name
NM_001077197.2	NP_001070665.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3
NM_001077196.2	NP_001070664.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 1
NM_001077358.2	NP_001070826.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 2
NM_016953.4	NP_058649.3	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4

PDE11A Protein Structure

GAF

PDEase_I

0
200
400
600
800
933 a.a.

Protein Preferred Names	Protein Names
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	cAMP and cGMP cyclic nucleotide phosphodiesterase 11A

Related Diseases

Diseases	Alias
Breast Ductal Adenoma
Hypothalamic Neoplasm	Hypothalamic Neoplasms Neoplasm Of The Hypothalamus Tumor Of Hypothalamus
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Cushing'S Disease Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Basophil Adenoma	Adenoma, Basophil Pituitary Gland Basophilic Adenoma
Csf1r-Related Brain Malformation And Osteopetrosis	Osteoporosis And Infantile Neuroaxonal Dystrophy
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Adrenal Gland Disease	Adrenal Gland Diseases Adrenal Gland Disorders
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Breast Adenoma	Ademoma - Breast
Acth-Independent Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenocortical Hyperplasia Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia Corticotropin-Independent Macronodular Adrenal Hyperplasia Cushing Syndrome Due To Macronodular Adrenal Hyperplasia AIMAH1 Aimah Massive Macronodular Adrenocortical Disease Mmad Primary Macronodular Adrenal Hyperplasia Cushing Syndrome, Adrenal, Due To Aimah Primary Bilateral Macronodular Adrenal Hyperplasia Acth-Independent Macronodular Adrenal Hyperplasia 1 Acth-Independent Cushing Syndrome Adrenal Cushing Syndrome Due To Aimah Acth-Independent Macronodular Adrenal Hyperplasia 2
Diencephalic Neoplasm	Malignant Diencephalic Neoplasm Malignant Diencephalic Tumor Tumor Of Diencephalon
Adrenal Cortex Disease	Adrenal Cortex Diseases
Melanotic Neurilemmoma	Melanotic Schwannoma Pigmented Neurilemmoma Pigmented Schwannoma
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Adrenocorticotropic Hormone-Independent Cushing Syndrome Corticotropin-Independent Cushing Syndrome
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Pigmented Nodular Adrenocortical Disease, Primary, 2	PPNAD2 Pigmented Micronodular Adrenocortical Disease, Primary, 2 Cushing Syndrome, Adrenal, Due To Ppnad2 Primary Pigmented Nodular Adrenocortical Disease 2 Adrenal Cushing Syndrome Due To Ppnad2 Primary Pigmented Micronodular Adrenocortical Disease 2 Primary Pigmented Nodular Adrenocortical Disease-2 Adrenocortical Disease, Nodular, Pigmented, Primary, Type 2
Mccune-Albright Syndrome	Mass Syndrome Polyostotic Fibrous Dysplasia MAS Fibrous Dysplasia Of Bone Albright Syndrome Mass Phenotype Overlap Connective Tissue Disease Mccune Albright Syndrome Osteitis Fibrosa Disseminata OCTD Albright'S Disease Pfd Pofd Albright'S Syndrome Mccune-Albright Syndrome, Somatic, Mosaic Albright'S Disease Of Bone Albright'S Syndrome With Precocious Puberty Albright-Mccune-Sternberg Syndrome Albright-Sternberg Syndrome Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty Gonadotropin-Independent Female-Limited Sexual Precocity Fibrous Dysplasia Polyostotic Fibrous Dysplasia, Polyostotic
Rhizomelic Chondrodysplasia Punctata, Type 3	Rhizomelic Chondrodysplasia Punctata Type 3 RCDP3 Alkyldihydroxyacetonephosphate Synthase Deficiency Alkylglycerone-Phosphate Synthase Deficiency Agps Deficiency Rhizomelic Chondrodysplasia Punctata 3 Chondrodysplasia Punctata, Rhizomelic, Type 3
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156434	PDE11A4-IN-1	Inhibitor	/	Unkown
HY-181589	PDE11A4-IN-2	Inhibitor	/	Unkown
HY-RS10202	PDE11A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10203	Pde11a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10204	Pde11a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180869	PDE11A modulator-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDE11A	VGNC	VGNC:44346
Mus musculus	PDE11A	MGD	MGI:3036251
Rattus norvegicus	PDE11A	RGD	RGD:621793
Bos taurus	PDE11A	VGNC	VGNC:32669
Others	PDE11A	NCBI