PDE11A - phosphodiesterase 11A Gene

Homo sapiens

Also known as PPNAD2

Gene ID: 50940 | Gene type: protein coding

About PDE11A

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:177,623,244-178,108,339 (from NCBI)

This gene has 12 transcripts (splice variants), 101 orthologues, 20 paralogues and is associated with 2 phenotypes. Biased expression in prostate (RPKM 3.1), fat (RPKM 1.5) and 11 other tissues.

Summary

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE11A Products(4)

mRNA	Protein	Name
NM_001077197.2	NP_001070665.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3
NM_001077196.2	NP_001070664.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 1
NM_001077358.2	NP_001070826.1	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 2
NM_016953.4	NP_058649.3	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4

PDE11A Protein Structure

GAF

PDEase_I

0
200
400
600
800
933 a.a.

Protein Preferred Names

Protein Names

dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

cAMP and cGMP cyclic nucleotide phosphodiesterase 11A

Related Diseases

Diseases

Alias

Breast Ductal Adenoma

Hypothalamic Neoplasm

Hypothalamic Neoplasms	Neoplasm Of The Hypothalamus
Tumor Of Hypothalamus

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Adrenal Cortex Adenoma	Corticotroph Pituitary Adenoma
Cushing'S Disease	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Basophil Adenoma

Adenoma, Basophil

Pituitary Gland Basophilic Adenoma

Csf1r-Related Brain Malformation And Osteopetrosis

Osteoporosis And Infantile Neuroaxonal Dystrophy

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Paraganglioma And Gastric Stromal Sarcoma

Carney-Stratakis Syndrome	Paraganglioma And Gastrointestinal Stromal Tumor
Carney Dyad	Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma
Paraganglioma And Gist	Carney-Stratakis Dyad
Gist-Paraganglioma Dyad	PGGSS
Paraganglioma, Gastric Stromal Sarcoma	Gastrointestinal Stromal Tumors

Adrenal Gland Disease

Adrenal Gland Diseases

Adrenal Gland Disorders

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Breast Adenoma

Ademoma - Breast

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

Diencephalic Neoplasm

Malignant Diencephalic Neoplasm	Malignant Diencephalic Tumor
Tumor Of Diencephalon

Adrenal Cortex Disease

Adrenal Cortex Diseases

Melanotic Neurilemmoma

Melanotic Schwannoma	Pigmented Neurilemmoma
Pigmented Schwannoma

Acth-Independent Cushing Syndrome

Adrenal Cushing Syndrome	Adrenocorticotropic Hormone-Independent Cushing Syndrome
Corticotropin-Independent Cushing Syndrome

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Testicular Disease

Testicular Dysfunction	Testicular Diseases
Disorder Of Testis	Testis Disorder
Testicular Disorders

Adrenal Carcinoma

Adrenal Cancer	Adrenal Gland Cancer
Malignant Neoplasm Of Adrenal Gland	Adrenal Gland Neoplasms
Carcinoma Of The Adrenal Gland	Adrenal Neoplasm
Malignant Adrenal Tumor	Neoplasm Of Adrenal Gland
Tumor Of The Adrenal Gland	Adrenal Gland Neoplasm
Adrenocortical Carcinoma	Adrenal Gland Malignancy
Suprarenal Cancer	Malignant Neoplasm Of Suprarenal Gland
Malignant Neoplasm Of Adrenal Gland, Unspecified	Malignant Tumour Of Adrenal Gland
Suprarenal Gland Cancer	Primary Malignant Neoplasm Of Adrenal Gland

Pigmented Nodular Adrenocortical Disease, Primary, 2

PPNAD2	Pigmented Micronodular Adrenocortical Disease, Primary, 2
Cushing Syndrome, Adrenal, Due To Ppnad2	Primary Pigmented Nodular Adrenocortical Disease 2
Adrenal Cushing Syndrome Due To Ppnad2	Primary Pigmented Micronodular Adrenocortical Disease 2
Primary Pigmented Nodular Adrenocortical Disease-2	Adrenocortical Disease, Nodular, Pigmented, Primary, Type 2

Mccune-Albright Syndrome

Mass Syndrome	Polyostotic Fibrous Dysplasia
MAS	Fibrous Dysplasia Of Bone
Albright Syndrome	Mass Phenotype
Overlap Connective Tissue Disease	Mccune Albright Syndrome
Osteitis Fibrosa Disseminata	OCTD
Albright'S Disease	Pfd
Pofd	Albright'S Syndrome
Mccune-Albright Syndrome, Somatic, Mosaic	Albright'S Disease Of Bone
Albright'S Syndrome With Precocious Puberty	Albright-Mccune-Sternberg Syndrome
Albright-Sternberg Syndrome	Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty
Gonadotropin-Independent Female-Limited Sexual Precocity	Fibrous Dysplasia Polyostotic
Fibrous Dysplasia, Polyostotic

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3	RCDP3
Alkyldihydroxyacetonephosphate Synthase Deficiency	Alkylglycerone-Phosphate Synthase Deficiency
Agps Deficiency	Rhizomelic Chondrodysplasia Punctata 3
Chondrodysplasia Punctata, Rhizomelic, Type 3

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156434	PDE11A4-IN-1	Inhibitor	/	Unkown
HY-RS10202	PDE11A Human Pre-designed siRNA Set A		/	Unkown
HY-RS10203	Pde11a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10204	Pde11a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDE11A	VGNC	VGNC:44346
Mus musculus	PDE11A	MGD	MGI:3036251
Rattus norvegicus	PDE11A	RGD	RGD:621793
Bos taurus	PDE11A	VGNC	VGNC:32669

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