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PCDH1 - protocadherin 1 Gene

Also Known as PC42; PCDH42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5097

About PCDH1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,853,090-141,878,410 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 33 paralogues. Ubiquitous expression in brain (RPKM 10.0), colon (RPKM 8.9) and 22 other tissues.

Summary

This gene belongs to the protocadherin subfamily within the Cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008]

PCDH1 Products (4)

mRNA	Protein	Name
NM_001278613.2	NP_001265542.1	protocadherin-1 isoform 3
NM_001278615.1	NP_001265544.1	protocadherin-1 isoform 4
NM_002587.5	NP_002578.2	protocadherin-1 isoform 1 precursor
NM_032420.5	NP_115796.2	protocadherin-1 isoform 2 precursor

PCDH1 Protein Structure

Cadherin_2

Cadherin

Protocadherin

0
200
400
600
800
1000
1060 a.a.

Protein Preferred Names	Protein Names
protocadherin-1	cadherin-like 1

Recombinant PCDH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71187	PCDH1 Protein, Human (HEK293, His)	Q08174 (T58-N852)	≥ 95%, as determined by reducing SDS-PAGE.

PCDH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89592	PCDH1 Antibody (YA8936)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Hantavirus Hemorrhagic Fever With Renal Syndrome	Hemorrhagic Fever, Russian Hemorrhagic Nephrosonephritis Hfrs Puumala Virus Nephropathy Hemorrhagic Fever With Renal Syndrome
Esophageal Atresia/Tracheoesophageal Fistula	Esophageal Atresia And/Or Tracheoesophageal Fistula Tracheoesophageal Fistula With Or Without Esohageal Atresia Esophageal Atresia / Tracheoesophageal Fistula Ea/Tef Esophageal Atresia With Tracheoesophageal Fistula Esophageal Atresia With Or Without Tracheoesophageal Fistula
Corneal Dystrophy, Endothelial, X-Linked	X-Linked Endothelial Corneal Dystrophy XECD Endothelial Corneal Dystrophy, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10121	PCDH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21682	Pcdh1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28200	Pcdh1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCDH1	RGD	RGD:1308490
Canis familiaris	PCDH1	VGNC	VGNC:44294
Bos taurus	PCDH1	VGNC	VGNC:32615
Felis catus	PCDH1	VGNC	VGNC:68715
Macaca mulatta	PCDH1	VGNC	VGNC:75775
Mus musculus	PCDH1	MGD	MGI:104692
Others	PCDH1	NCBI