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HERC5 - HECT and RLD domain containing E3 ubiquitin protein ligase 5 Gene

Also Known as CEB1; CEBP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51191

About HERC5

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,457,119-88,506,163 (from NCBI)

This gene has 5 transcripts (splice variants), 82 orthologues and 24 paralogues. Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues.

Summary

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein Ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the Antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]

HERC5 Products (1)

mRNA	Protein	Name
NM_016323.4	NP_057407.2	E3 ISG15--protein ligase HERC5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ISG15 transferase activity	IDA IDA: Inferred from direct assay	16407192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20133869	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15331633	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ISG15-protein conjugation	IDA IDA: Inferred from direct assay	16407192	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	28724761	GOA
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	15331633	GOA
involved in regulation of defense response to virus	IDA IDA: Inferred from direct assay	20308324	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	16407192	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10581175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HERC5 Protein Structure

RCC1

HECT

0
200
400
600
800
1024 a.a.

Protein Preferred Names	Protein Names
E3 ISG15--protein ligase HERC5	HECT domain and RCC1-like domain-containing protein 5

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Dyskeratosis Congenita, Autosomal Recessive 5	Dyskeratosis Congenita, Autosomal Dominant, 4 DKCB5 Autosomal Dominant Dyskeratosis Congenita 4 DKCA4 Autosomal Recessive Dyskeratosis Congenita 5 Dyskeratosis Congenita, Autosomal Recessive, 5 Dyskeratosis Congenita, Autosomal Dominant 4 Dyskeratosis Congenita, Autosomal Recessive, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06130	HERC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16311	Herc6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown