HERC5 - HECT and RLD domain containing E3 ubiquitin protein ligase 5 Gene

Homo sapiens

Also known as CEB1; CEBP1

Gene ID: 51191 | Gene type: protein coding

About HERC5

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,457,119-88,506,163 (from NCBI)

This gene has 5 transcripts (splice variants), 82 orthologues and 24 paralogues. Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues.

Summary

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the Antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]

HERC5 Products(1)

mRNA	Protein	Name
NM_016323.4	NP_057407.2	E3 ISG15--protein ligase HERC5

HERC5 Protein Structure

RCC1

HECT

0
200
400
600
800
1024 a.a.

Protein Preferred Names

Protein Names

E3 ISG15--protein ligase HERC5

HECT domain and RCC1-like domain-containing protein 5

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4	DKCB5
Autosomal Dominant Dyskeratosis Congenita 4	DKCA4
Autosomal Recessive Dyskeratosis Congenita 5	Dyskeratosis Congenita, Autosomal Recessive, 5
Dyskeratosis Congenita, Autosomal Dominant 4	Dyskeratosis Congenita, Autosomal Recessive, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06130	HERC5 Human Pre-designed siRNA Set A		/	Unkown

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