CKLF - chemokine like factor Gene

Also Known as C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51192

About CKLF

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:66,552,563-66,566,287 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 18.6), testis (RPKM 17.1) and 24 other tissues.

Summary

The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

CKLF Products (5)

mRNA Protein Name
NM_001040138.3 NP_001035228.1 chemokine-like factor isoform e
NM_016326.3 NP_057410.1 chemokine-like factor isoform c
NM_016951.4 NP_058647.1 chemokine-like factor isoform a
NM_181640.2 NP_857591.1 chemokine-like factor isoform b
NM_181641.2 NP_857592.1 chemokine-like factor isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
11415443 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in lymphocyte chemotaxis IDA
IDA: Inferred from direct assay
11415443 GOA
involved in macrophage chemotaxis IDA
IDA: Inferred from direct assay
11415443 GOA
involved in neutrophil chemotaxis IDA
IDA: Inferred from direct assay
11415443 GOA
involved in secretion by cell IDA
IDA: Inferred from direct assay
11415443 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
11415443 GOA
located in membrane IDA
IDA: Inferred from direct assay
11415443 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chemokine-like factor

  • chemokine-like factor 1

Related Diseases

Diseases Alias
Brugada Syndrome 2

  • BRGDA2

  • Brugada Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3418 CKLF1-C27 98.02% Unkown
HY-P3982 CKLF1-C19 Chemical 99.11% Unkown
HY-RS07342 KLF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123357 IMM-H004 Inhibitor / Unkown
HY-P3418A CKLF1-C27 TFA / Unkown
HY-RS02737 CKLF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16676 Klf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18393 Klf15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CKLF MGD MGI:1922708
Canis familiaris CKLF VGNC VGNC:39290
Rattus norvegicus CKLF RGD RGD:620708
Others CKLF NCBI