ACP6 - acid phosphatase 6, lysophosphatidic Gene

Also Known as LPAP; ACPL1; PACPL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51205

About ACP6

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:147,629,658-147,670,524 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the histidine Acid Phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]

ACP6 Products (2)

mRNA	Protein	Name
NM_001323625.2	NP_001310554.1	lysophosphatidic acid phosphatase type 6 isoform 2
NM_016361.5	NP_057445.4	lysophosphatidic acid phosphatase type 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lysophosphatidic acid phosphatase activity	IDA IDA: Inferred from direct assay	10506173	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lysobisphosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	23807634	GOA
involved in phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	10506173	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12010880	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	10506173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACP6 Protein Structure

His_Phos_2

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
lysophosphatidic acid phosphatase type 6	acid phosphatase-like protein 1

Related Diseases

Diseases	Alias
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb	Chromosome 1q21.1 Deletion Syndrome 1q21.1 Microdeletion Syndrome Monosomy 1q21.1 1q21.1 Microdeletion Chromosome 1q21.1 Microdeletion Syndrome 1q21.1 Contiguous Gene Deletion 1q21.1 Deletion Del(1)(Q21) 1q21.1 Deletion Syndrome
Duodenal Atresia	Duodenal Stenosis Familial Duodenal Atresia
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00191	ACP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22095	Acp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28615	Acp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ACP6	VGNC	VGNC:59527
Mus musculus	ACP6	MGD	MGI:1931010
Bos taurus	ACP6	VGNC	VGNC:52602
Rattus norvegicus	ACP6	RGD	RGD:1306336
Macaca mulatta	ACP6	VGNC	VGNC:69548
Canis familiaris	ACP6	VGNC	VGNC:54914
Others	ACP6	NCBI