RNF181 - ring finger protein 181 Gene

Also Known as HSPC238

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51255

About RNF181

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,595,745-85,597,708 (from NCBI)

This gene has 6 transcripts (splice variants), 155 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 21.9), placenta (RPKM 18.7) and 25 other tissues.

Summary

RNF181 binds the Integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin Ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

RNF181 Products (1)

mRNA Protein Name
NM_016494.4 NP_057578.1 E3 ubiquitin-protein ligase RNF181

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19690564 GOA
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
26711259 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
24811749 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
24105792 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
24105792 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF181 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (75 - 117)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF181

  • RING-type E3 ubiquitin transferase RNF181

RNF181 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF181 Q9P0P0 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12066 RNF181 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNF181 VGNC VGNC:45647
Rattus norvegicus RNF181 RGD RGD:1359698
Macaca mulatta RNF181 VGNC VGNC:107214
Mus musculus RNF181 MGD MGI:1913760
Felis catus RNF181 VGNC VGNC:64684
Bos taurus RNF181 VGNC VGNC:34039
Others RNF181 NCBI