MEX3C - mex-3 RNA binding family member C Gene

Also Known as RKHD2; BM-013; MEX-3C; RNF194

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51320

About MEX3C

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:51,174,550-51,197,681 (from NCBI)

This gene has 3 transcripts (splice variants), 144 orthologues and 3 paralogues. Broad expression in testis (RPKM 32.6), lymph node (RPKM 11.1) and 24 other tissues.

Summary

This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

MEX3C Products (1)

mRNA	Protein	Name
NM_016626.5	NP_057710.3	RNA-binding E3 ubiquitin-protein ligase MEX3C

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	23408853	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22863774	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	22863774	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEX3C Protein Structure

KH_1

zf-C3HC4_3

0
200
400
600
659 a.a.

Protein Preferred Names	Protein Names
RNA-binding E3 ubiquitin-protein ligase MEX3C	RING finger and KH domain-containing protein 2

MEX3C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MEX3C	Q5U5Q3	USP7	Homo sapiens	Q93009	Anti Bait CoIP	22863774
Intra	MEX3C	Q5U5Q3	USP7	Homo sapiens	Q93009	Anti Tag CoIP	22863774
Intra	MEX3C	Q5U5Q3	YWHAE	Homo sapiens	P62258	Pull Down	22863774
Intra	MEX3C	Q5U5Q3	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MEX3C	Q5U5Q3	RUNX3	Homo sapiens	Q13761	Anti Bait CoIP	38424632

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08374	MEX3C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEX3C	RGD	RGD:1309023
Canis familiaris	MEX3C	VGNC	VGNC:43185
Felis catus	MEX3C	VGNC	VGNC:63469
Bos taurus	MEX3C	VGNC	VGNC:31420
Mus musculus	MEX3C	MGD	MGI:2652843
Macaca mulatta	MEX3C	VGNC	VGNC:74597