2. Gene
  3. PCYOX1 - prenylcysteine oxidase 1 Gene

PCYOX1 - prenylcysteine oxidase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PCL1

Gene ID: 51449 | Gene type: protein coding

About PCYOX1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,257,915-70,281,185 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues.

Summary

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

PCYOX1 Products(1)

mRNA Protein Name
NM_016297.4 NP_057381.3 prenylcysteine oxidase 1 precursor

PCYOX1 Protein Structure

NAD_binding_8

NAD_binding_8: NAD(P)-binding Rossmann-like domain (39 - 106)

Prenylcys_lyase

Prenylcys_lyase: Prenylcysteine lyase (128 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

prenylcysteine oxidase 1

prenylcysteine lyase

Related Diseases

Diseases Alias
Coenzyme Q10 Deficiency, Primary, 9

COQ10D9

Primary Coenzyme Q10 Deficiency 9
Developmental And Epileptic Encephalopathy 33

DEE33

Epileptic Encephalopathy, Early Infantile, 33

Eiee33

Developmental And Epileptic Encephalopathy, 33

Early Infantile Epileptic Encephalopathy 33

Encephalopathy, Epileptic, Early Infantile, Type 33
Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency

IMD50

Immunodeficiency 50, X-Linked Recessive

Cid Due To Moesin Deficiency

Msn-Related Combined Immunodeficiency

X-Linked Moesin-Associated Immunodeficiency

Immunodeficiency 50 X Linked Recessive
Charcot-Marie-Tooth Disease, Axonal, Type 2cc

Charcot-Marie-Tooth Disease Axonal Type 2cc

CMT2CC

Charcot-Marie-Tooth Neuropathy, Type 2cc

Charcot-Marie-Tooth Neuropathy Type 2cc

Charcot-Marie-Tooth Disease 2cc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10179 PCYOX1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PCYOX1 VGNC VGNC:44327
Rattus norvegicus PCYOX1 RGD RGD:628652
Bos taurus PCYOX1 VGNC VGNC:32650
Macaca mulatta PCYOX1 VGNC VGNC:75658
Mus musculus PCYOX1 MGD MGI:1914131
Felis catus PCYOX1 VGNC VGNC:64074