GULP1 - GULP PTB domain containing engulfment adaptor 1 Gene

Also Known as CED6; GULP; CED-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51454

About GULP1

Cytogenetic location: 2q32.1-q32.2 Genomic coordinates (GRCh38): 2:188,291,874-188,595,926 (from NCBI)

This gene has 20 transcripts (splice variants), 235 orthologues and 11 paralogues. Broad expression in endometrium (RPKM 8.3), prostate (RPKM 7.5) and 22 other tissues.

Summary

The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GULP1 Products (32)

mRNA Protein Name
NM_001252668.2 NP_001239597.1 PTB domain-containing engulfment adapter protein 1 isoform b
NM_001252669.2 NP_001239598.1 PTB domain-containing engulfment adapter protein 1 isoform c
NM_001375925.1 NP_001362854.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375926.1 NP_001362855.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375927.1 NP_001362856.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375928.1 NP_001362857.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375929.1 NP_001362858.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375930.1 NP_001362859.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375931.1 NP_001362860.1 PTB domain-containing engulfment adapter protein 1 isoform a
NM_001375932.1 NP_001362861.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375933.1 NP_001362862.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375934.1 NP_001362863.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375935.1 NP_001362864.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375936.1 NP_001362865.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375937.1 NP_001362866.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375938.1 NP_001362867.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375939.1 NP_001362868.1 PTB domain-containing engulfment adapter protein 1 isoform d
NM_001375940.1 NP_001362869.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375941.1 NP_001362870.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375942.1 NP_001362871.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375943.1 NP_001362872.1 PTB domain-containing engulfment adapter protein 1 isoform e
NM_001375944.1 NP_001362873.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375945.1 NP_001362874.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375946.1 NP_001362875.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375947.1 NP_001362876.1 PTB domain-containing engulfment adapter protein 1 isoform f
NM_001375948.1 NP_001362877.1 PTB domain-containing engulfment adapter protein 1 isoform g
NM_001375949.1 NP_001362878.1 PTB domain-containing engulfment adapter protein 1 isoform g
NM_001375950.1 NP_001362879.1 PTB domain-containing engulfment adapter protein 1 isoform h
NM_001375951.1 NP_001362880.1 PTB domain-containing engulfment adapter protein 1 isoform i
NM_001375952.1 NP_001362881.1 PTB domain-containing engulfment adapter protein 1 isoform j
NM_001375953.1 NP_001362882.1 PTB domain-containing engulfment adapter protein 1 isoform k
NM_016315.4 NP_057399.1 PTB domain-containing engulfment adapter protein 1 isoform a

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within phagocytosis, engulfment IDA
IDA: Inferred from direct assay
11729193 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GULP1 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (27 - 154)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

PTB domain-containing engulfment adapter protein 1

  • GULP, engulfment adaptor PTB domain containing 1

Related Diseases

Diseases Alias
Thyroid Dyshormonogenesis 4

  • Deiodinase Deficiency

  • TDH4

  • Iodotyrosine Dehalogenase Deficiency

  • Thyroid Hormonogenesis, Genetic Defect In, 4

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4

  • Genetic Defect In Thyroid Hormonogenesis 4

  • Chdh4

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 4

  • Genetic Defect In Thyroid Hormonogenesis Type 4
Niemann-Pick Disease, Type B

  • Niemann-Pick Disease Type B

  • Acid Sphingomyelinase Deficiency, Visceral Type

  • Asmd, Visceral Type

  • Niemann Pick Disease Type B

  • Chronic Visceral Acid Sphingomyelinase Deficiency

  • Chronic Visceral Asmd

  • Npd-B

  • Niemann-Pick Disease B

  • NPDB

  • Niemann-Pick Disease Adult Non-Neuronopathic Form

  • Niemann-Pick Disease Intermediate With Visceral Involvement And Rapid Progression

  • Niemann-Pick Disease Type E

  • Niemann-Pick Disease Type F

  • Niemann-Pick Disease Type I

  • Niemann-Pick Disease Visceral Form

  • Npb

  • Sphingomyelinase Deficiency

  • Sphingomyelin Lipidosis

  • Niemann-Picks Disease Type B

  • Niemann-Pick Disease, Type E

  • Niemann-Pick Diseases

  • Niemann-Pick Disease, Type A
Familial Thyroid Dyshormonogenesis

  • Thyroid Dyshormonogenesis

  • Familial Dyshormonogenetic Goiter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05926 GULP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GULP1 VGNC VGNC:62741
Mus musculus GULP1 MGD MGI:1920407
Bos taurus GULP1 VGNC VGNC:50050
Canis familiaris GULP1 VGNC VGNC:53097
Macaca mulatta GULP1 VGNC VGNC:73193
Rattus norvegicus GULP1 RGD RGD:1306380
Others GULP1 NCBI