PDE7A - phosphodiesterase 7A Gene

Also Known as HCP1; PDE7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5150

About PDE7A

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:65,714,334-65,842,064 (from NCBI)

This gene has 8 transcripts (splice variants), 240 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 14.6), appendix (RPKM 7.7) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

PDE7A Products (5)

mRNA Protein Name
NM_002603.4 NP_002594.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform a precursor
NM_001242318.3 NP_001229247.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c
NM_002604.2
XM_011517540.4 XP_011515842.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1
XM_017013538.3 XP_016869027.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
8389765 GOA
Biological Process GO Annotation Evidence References Source
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
9195912 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE7A Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (211 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

  • TM22

  • high affinity cAMP-specific PDE 1

  • phosphodiesterase isozyme 7

Related Diseases

Diseases Alias
Low Compliance Bladder

  • Overactive Bladder

  • Hyperactivity Of Bladder

  • Hypertonic Bladder

  • Hypertonicity Of Bladder

  • Low Bladder Compliance

  • Oab - [Overactive Bladder]
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Microphthalmia, Isolated 1

  • Isolated Microphthalmia 1

  • MCOP1

  • Mcop

  • Anophthalmia, Clinical, Isolated

  • Microphthalmos, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus PDE7A VGNC VGNC:68764
Rattus norvegicus PDE7A RGD RGD:68391
Mus musculus PDE7A MGD MGI:1202402
Bos taurus PDE7A VGNC VGNC:32685
Macaca mulatta PDE7A VGNC VGNC:75922
Canis familiaris PDE7A VGNC VGNC:44363
Others PDE7A NCBI