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PHF7 - PHD finger protein 7 Gene

Also Known as HSPC045; HSPC226; NYD-SP6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51533

About PHF7

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,410,660-52,423,641 (from NCBI)

This gene has 10 transcripts (splice variants), 213 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 610.5).

Summary

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

PHF7 Products (4)

mRNA	Protein	Name
NM_001278221.3	NP_001265150.1	PHD finger protein 7 isoform 2
NM_001321126.2	NP_001308055.1	PHD finger protein 7 isoform 1
NM_001321127.2	NP_001308056.1	PHD finger protein 7 isoform 1
NM_016483.7	NP_057567.3	PHD finger protein 7 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF7 Protein Structure

zf-HC5HC2H

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
PHD finger protein 7	testicular secretory protein Li 34

PHF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHF7	Q9BWX1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PHF7	Q9BWX1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PHF7	Q9BWX1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	PHF7	Q9BWX1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Prey Pooling	25416956
Intra	PHF7	Q9BWX1	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	PHF7	Q9BWX1	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	PHF7	Q9BWX1	GRN	Homo sapiens	P28799	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Granulomatous Orchitis	Non-Specific Granulomatous Orchitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10430	PHF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PHF7	RGD	RGD:1308638
Felis catus	PHF7	VGNC	VGNC:64146
Bos taurus	PHF7	VGNC	VGNC:32827
Canis familiaris	PHF7	VGNC	VGNC:44493
Mus musculus	PHF7	MGD	MGI:1919088
Macaca mulatta	PHF7	VGNC	VGNC:75828
Others	PHF7	NCBI