Ppp2r1a - protein phosphatase 2, regulatory subunit A, alpha Gene

Also Known as PP2A; PR65; 6330556D22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 51792

Summary

Enables protein serine/threonine Phosphatase activity. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and glutamatergic synapse. Part of protein Phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to human PPP2R1A (protein Phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2r1a Products (1)

mRNA Protein Name
NM_016891.3 NP_058587.1 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12885400 MGI
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12944463 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell homeostasis IMP
IMP: Inferred from mutant phenotype
26974206 MGI
acts upstream of or within female meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
24899574 MGI
acts upstream of or within meiotic sister chromatid cohesion, centromeric IMP
IMP: Inferred from mutant phenotype
24899574 MGI
acts upstream of or within meiotic spindle elongation IMP
IMP: Inferred from mutant phenotype
24899574 MGI
acts upstream of or within mitotic sister chromatid separation IMP
IMP: Inferred from mutant phenotype
24899574 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
26974206 MGI
acts upstream of or within peptidyl-serine dephosphorylation IDA
IDA: Inferred from direct assay
12944463 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
12944463 MGI
acts upstream of or within regulation of meiotic cell cycle process involved in oocyte maturation IMP
IMP: Inferred from mutant phenotype
24899574 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
12885400 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24413018 MGI
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
16717086 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

  • protein phosphatase PP2A

  • serine/threonine protein phosphatase A subunit type 2A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11009 PPP2R1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180485 PROTAC D16-M1P2 / Unkown
HY-RS18724 Ppp2r1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25211 Ppp2r1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp2r1a NCBI NCBI:5518