SERPINB9 - serpin family B member 9 Gene

Also Known as PI9; CAP3; PI-9; CAP-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5272

About SERPINB9

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,887,270-2,903,309 (from NCBI)

This gene has 1 transcript (splice variant), 150 orthologues and 36 paralogues. Broad expression in placenta (RPKM 26.1), appendix (RPKM 19.1) and 21 other tissues.

Summary

This gene encodes a member of the Serine Protease Inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

SERPINB9 Products (1)

mRNA Protein Name
NM_004155.6 NP_004146.1 serpin B9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: Inferred from direct assay
10790428 GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17479112 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
16267761 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17479112 GOA
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
8910377 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
17237823 GOA
involved in immune response IDA
IDA: Inferred from direct assay
16306080 GOA
involved in mast cell mediated immunity IEP
IEP: Inferred from expression pattern
15739160 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17237823 GOA
involved in negative regulation of endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21795594 GOA
involved in protection from natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
21795594 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11463822 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11485349 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
16267761 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11463822 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB9 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (7 - 376)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

serpin B9

  • cytoplasmic antiproteinase 3

SERPINB9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERPINB9 P50453 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
25416956
Intra
SERPINB9 P50453 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
32296183
Intra
SERPINB9 P50453 TRAF5 Homo sapiens O00463
Y2H Array
32296183
Intra
SERPINB9 P50453 ST3GAL3 Homo sapiens Q11203
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINB9 Proteins

Cat. No. Product Name Accession Purity
HY-P71306 Serpin B9 Protein, Human (HEK293, His) P50453 (M1-P376) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pituitary Adenoma 2, Growth Hormone-Secreting

  • PITA2

  • Acromegaly Due To Pituitary Adenoma 2

  • Acromegaly, X-Linked

  • Growth Hormone Secreting Pituitary Adenoma 2

  • Pituitary Adenoma, Growth Hormone-Secreting, 2

  • Pituitary Adenoma 2, Gh-Secreting

  • Gh-Secreting Pituitary Adenoma 2

  • X-Linked Acromegaly

  • Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Patella, Chondromalacia Of

  • Chondromalacia Patellae

  • Chondromalacia Of Patella

  • Softening Of Articular Cartilage Of Patella

  • Patellofemoral Pain Syndrome

  • Patellofemoral Chondromalacia
Palmoplantar Keratoderma And Congenital Alopecia 2

  • Cataract-Alopecia-Sclerodactyly Syndrome

  • Cass

  • Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia

  • PPKCA2

  • Autosomal Recessive Palmoplantar Hyperkeratosis And Congenital Alopecia

  • Palmoplantar Keratoderma And Congenital Alopecia, Wallis Type

  • Ppk-Ca, Wallis Type

  • Cataract, Alopecia, Sclerodactyly

  • Ppkca, Wallis Type

  • Ppkca Wallis Type

  • Cataract, Alopecia, Sclerodactyly Syndrome
Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

  • Pediatric Cns Pnet

  • Childhood Central Nervous System Primitive Neuroectodermal Tumor
Severe Congenital Neutropenia 7

  • Autosomal Recessive Severe Congenital Neutropenia Due To Csf3r Deficiency

  • Scn7
Reticulosarcoma

  • Histiocytic Lymphoma

  • Large-Cell Lymphomas

  • Lymphoma, Large-Cell

  • Lymphoma Large Cell

  • Diffuse Large B-Cell Lymphoma

  • Histiocytic Sarcoma
Ewing Sarcoma

  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12717 SERPINB9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20669 Serpinb9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27180 Serpinb9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SERPINB9 VGNC VGNC:46033
Felis catus SERPINB9 VGNC VGNC:68840
Macaca mulatta SERPINB9 VGNC VGNC:77371
Rattus norvegicus SERPINB9 RGD RGD:1549730
Bos taurus SERPINB9 VGNC VGNC:54235
Others SERPINB9 NCBI