IL17D - interleukin 17D Gene

Also Known as IL-17D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53342

About IL17D

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,701,513-20,723,098 (from NCBI)

This gene has 4 transcripts (splice variants), 163 orthologues and 5 paralogues. Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues.

Summary

The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of Other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

IL17D Products (7)

mRNA Protein Name
NM_001385221.1 NP_001372150.1 interleukin-17D isoform a precursor
NM_001385222.1 NP_001372151.1 interleukin-17D isoform b precursor
NM_001385223.1 NP_001372152.1 interleukin-17D isoform c precursor
NM_001385224.1 NP_001372153.1 interleukin-17D isoform c precursor
NM_001385225.1 NP_001372154.1 interleukin-17D isoform d
NM_001386973.1 NP_001373902.1 interleukin-17D isoform e
NM_138284.2 NP_612141.1 interleukin-17D isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
12097364 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12097364 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
12097364 GOA
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IDA
IDA: Inferred from direct assay
12097364 GOA
involved in negative regulation of hemopoiesis IDA
IDA: Inferred from direct assay
12097364 GOA
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
12097364 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
12097364 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
12097364 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
12097364 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12097364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17D Protein Structure

IL17

IL17: Interleukin-17 (89 - 171)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

interleukin-17D

Recombinant IL17D Proteins

Cat. No. Product Name Accession Purity
HY-P70587 IL-17D Protein, Human Q8TAD2 (A18-P202) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700106AF Animal-Free IL-17D Protein, Human (His) Q8TAD2 (A18-P202) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hidradenitis Suppurativa

  • Acne Inversa

  • Suppurative Hidradenitis

  • Acne Inversa, Familial

  • Apocrinitis

  • Hidradenitides, Suppurative

  • Hidradenitis, Suppurative

  • Suppurative Hidradenitides

  • Inverse Acne
Psoriasis
Hidradenitis

  • Hydradenitis
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06700 IL17D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19207 Il17d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25696 Il17d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL17D RGD RGD:1595926
Mus musculus IL17D MGD MGI:2446510
Bos taurus IL17D VGNC VGNC:30120
Others IL17D NCBI