Nono - non-POU-domain-containing, octamer binding protein Gene

Also Known as nonA; NRB54; P54NRB

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53610

Summary

Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and regulation of circadian rhythm. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; central nervous system ganglion; gut; sensory organ; and testis. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Apr 2022]

Nono Products (2)

mRNA Protein Name
NM_001252518.1 NP_001239447.1 non-POU domain-containing octamer-binding protein
NM_023144.2 NP_075633.2 non-POU domain-containing octamer-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
19389484 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8626664 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22966205 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22966205 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
19389484 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15860628 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

non-POU domain-containing octamer-binding protein

Nono Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nono Q99K48 Spi1 Mus musculus P17433
Pull Down
8626664
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153918 (R)-SKBG-1 Inhibitor 99.68% Unkown
HY-153918A (S)-SKBG-1 99.01% Unkown
HY-RS09425 NONO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18626 Nono Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25112 Nono Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991327 PAT-LM1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nono NCBI NCBI:4841