Map3k14 - mitogen-activated protein kinase kinase kinase 14 Gene

Also Known as Nik; aly

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53859

Summary

Enables NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Map3k14 Products (1)

mRNA Protein Name
NM_016896.3 NP_058592.1 mitogen-activated protein kinase kinase kinase 14

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11239468 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11239468 MGI
Biological Process GO Annotation Evidence References Source
involved in immune response IDA
IDA: Inferred from direct assay
11239468 MGI
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11239468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 14

  • NF kappa B-inducing kinase

  • NF-kappa-beta-inducing kinase

  • Nfkb inducing kinase

  • alymphoplasia

  • serine/threonine-protein kinase NIK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124865 MAP3K14-IN-1 Inhibitor / Unkown
HY-RS08051 MAP3K14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20213 Map3k14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26718 Map3k14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k14 NCBI NCBI:9020