YBEY - ybeY metalloendoribonuclease Gene

Also Known as C21orf57

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54059

About YBEY

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,286,342-46,313,225 (from NCBI)

This gene has 8 transcripts (splice variants), 188 orthologues and 2 paralogues. Broad expression in testis (RPKM 8.0), thyroid (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

YBEY Products (7)

mRNA Protein Name
NM_001006114.3 NP_001006114.1 endoribonuclease YbeY isoform 2
NM_001314022.2 NP_001300951.1 endoribonuclease YbeY isoform 3
NM_001314023.2 NP_001300952.1 endoribonuclease YbeY isoform 4
NM_001314024.2 NP_001300953.1 endoribonuclease YbeY isoform 5
NM_001314025.2 NP_001300954.1 endoribonuclease YbeY isoform 1
NM_001314026.2 NP_001300955.1 endoribonuclease YbeY isoform 2
NM_058181.3 NP_478061.1 endoribonuclease YbeY isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
28153719 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22042635 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YBEY Protein Structure

UPF0054

UPF0054: Uncharacterized protein family UPF0054 (19 - 149)

  • 0
  • 100
  • 167 a.a.
Protein Preferred Names Protein Names

endoribonuclease YbeY

  • putative metalloprotease C21orf57

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15915 YBEY Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris YBEY VGNC VGNC:53052
Macaca mulatta YBEY VGNC VGNC:78866
Rattus norvegicus YBEY RGD RGD:1308722
Bos taurus YBEY VGNC VGNC:54568
Mus musculus YBEY MGD MGI:2656825
Others YBEY NCBI