Avpr1a - arginine vasopressin receptor 1A Gene

Also Known as V1a; AVPR; V1aR; Avpr1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54140

About Avpr1a

Chromosome 10: 122,284,404-122,289,357 forward strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 264 orthologues, 16 paralogues and is associated with 20 phenotypes. Biased expression in liver adult (RPKM 15.9), bladder adult (RPKM 11.1) and 13 other tissues.

Summary

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]

Avpr1a Products (1)

mRNA Protein Name
NM_016847.2 NP_058543.2 vasopressin V1a receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
26531127 MGI
acts upstream of or within regulation of systemic arterial blood pressure by vasopressin IGI
IGI: Inferred from genetic interaction
12486173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Avpr1a Protein Structure

7tmA_V1aR

7tmA_V1aR: cd15385 (51 - 363)

7tmA_V1aR

7tmA_V1aR: cd15385 (52 - 78)

7tmA_V1aR

7tmA_V1aR: cd15385 (85 - 112)

7tmA_V1aR

7tmA_V1aR: cd15385 (123 - 153)

7tmA_V1aR

7tmA_V1aR: cd15385 (165 - 186)

7tmA_V1aR

7tmA_V1aR: cd15385 (214 - 243)

7tmA_V1aR

7tmA_V1aR: cd15385 (288 - 318)

7tmA_V1aR

7tmA_V1aR: cd15385 (331 - 356)

DUF1856

DUF1856: pfam08983 (376 - 422)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

vasopressin V1a receptor

  • AVPR V1a

  • V1a arginine vasopressin receptor

  • antidiuretic hormone receptor 1a

  • vascular/hepatic-type arginine vasopressin receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0049A Argipressin diacetate / Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-RS01281 AVPR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01282 Avpr1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01283 Avpr1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Avpr1a NCBI NCBI:552