Hgfac - hepatocyte growth factor activator Gene

Also Known as HGFA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54426

Summary

This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]

Hgfac Products (1)

mRNA Protein Name
NM_019447.3 NP_062320.2 hepatocyte growth factor activator preproprotein

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12923239 MGI
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
12923239 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte growth factor activator

  • HGF activator

Recombinant Hgfac Proteins

Cat. No. Product Name Accession Purity
HY-P77960 HGFA/HGF Activator Protein, Mouse (HEK293, His) Q9R098 (Q35-S653) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06153 HGFAC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19010 Hgfac Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25499 Hgfac Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hgfac NCBI NCBI:3083