HGFAC - HGF activator Gene

Homo sapiens

Also known as HGFA

Gene ID: 3083 | Gene type: protein coding

About HGFAC

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,441,005-3,449,486 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 16 paralogues. Restricted expression toward liver (RPKM 27.9).

Summary

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HGFAC Products(2)

mRNA	Protein	Name
NM_001297439.2	NP_001284368.1	hepatocyte growth factor activator isoform 1 preproprotein
NM_001528.4	NP_001519.1	hepatocyte growth factor activator isoform 2 preproprotein

HGFAC Protein Structure

fn2

EGF

fn1

EGF

Kringle

Trypsin

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

hepatocyte growth factor activator

Recombinant HGFAC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76380	HGFA/HGF Activator Protein, Human (HEK293, His)	Q04756 (M1-S655)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 97

DFNB97	Autosomal Recessive Nonsyndromic Deafness 97
Autosomal Recessive Deafness 97	Deafness, Autosomal Recessive, 97
Deafness, Autosomal Recessive, Type 97

Malignant Peripheral Nerve Sheath Tumor

Mpnst	Malignant Neurilemmoma
Neurofibrosarcoma	Malignant Neurofibroma
Malignant Schwannoma	Neurogenic Sarcoma
Schwannoma, Malignant	Malignant Neoplasm Of The Peripheral Nerve Sheath
Malignant Peripheral Nerve Sheath Tumors

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06153	HGFAC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HGFAC	VGNC	VGNC:73374
Mus musculus	HGFAC	MGD	MGI:1859281
Bos taurus	HGFAC	VGNC	VGNC:53764
Felis catus	HGFAC	VGNC	VGNC:67565
Rattus norvegicus	HGFAC	RGD	RGD:70909
Canis familiaris	HGFAC	VGNC	VGNC:41675
Macaca fascicularis	HGFAC	NCBI
Others	HGFAC	NCBI

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