HGFAC - HGF activator Gene

Also Known as HGFA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3083

About HGFAC

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,441,005-3,449,486 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 16 paralogues. Restricted expression toward liver (RPKM 27.9).

Summary

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HGFAC Products (2)

mRNA Protein Name
NM_001297439.2 NP_001284368.1 hepatocyte growth factor activator isoform 1 preproprotein
NM_001528.4 NP_001519.1 hepatocyte growth factor activator isoform 2 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15713485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HGFAC Protein Structure

fn2

fn2: Fibronectin type II domain (108 - 148)

EGF

EGF: EGF-like domain (164 - 195)

fn1

fn1: Fibronectin type I domain (202 - 237)

EGF

EGF: EGF-like domain (245 - 276)

Kringle

Kringle: Kringle domain (286 - 367)

Trypsin

Trypsin: Trypsin (408 - 641)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

hepatocyte growth factor activator

HGFAC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Y2H Prey Pooling
32296183
Intra
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Validated Y2H
32296183
Intra
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Y2H Array
32296183
Intra
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Intra
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HGFAC Proteins

Cat. No. Product Name Accession Purity
HY-P76380 HGFA/HGF Activator Protein, Human (HEK293, His) Q04756/NP_001519.1 (Q36-S655) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 97

  • DFNB97

  • Autosomal Recessive Nonsyndromic Deafness 97

  • Autosomal Recessive Deafness 97

  • Deafness, Autosomal Recessive, 97

  • Deafness, Autosomal Recessive, Type 97
Malignant Peripheral Nerve Sheath Tumor

  • Mpnst

  • Malignant Neurilemmoma

  • Neurofibrosarcoma

  • Malignant Neurofibroma

  • Malignant Schwannoma

  • Neurogenic Sarcoma

  • Schwannoma, Malignant

  • Malignant Neoplasm Of The Peripheral Nerve Sheath

  • Malignant Peripheral Nerve Sheath Tumors
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06153 HGFAC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19010 Hgfac Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25499 Hgfac Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HGFAC VGNC VGNC:73374
Mus musculus HGFAC MGD MGI:1859281
Bos taurus HGFAC VGNC VGNC:53764
Felis catus HGFAC VGNC VGNC:67565
Rattus norvegicus HGFAC RGD RGD:70909
Canis familiaris HGFAC VGNC VGNC:41675
Others HGFAC NCBI