TMED9 - transmembrane p24 trafficking protein 9 Gene

Also Known as p25; GMP25; p24a2; HSGP25L2G; p24alpha2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54732

About TMED9

This gene has 6 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 102.0), colon (RPKM 69.9) and 25 other tissues.

Summary

This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of MicroRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]

TMED9 Products (1)

mRNA Protein Name
NM_017510.6 NP_059980.2 transmembrane emp24 domain-containing protein 9 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16595549 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
21545355 GOA
Biological Process GO Annotation Evidence References Source
involved in COPI coating of Golgi vesicle IMP
IMP: Inferred from mutant phenotype
18287528 GOA
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
18287528 GOA
NOT involved in early endosome to Golgi transport IMP
IMP: Inferred from mutant phenotype
18287528 GOA
involved in positive regulation of organelle organization IMP
IMP: Inferred from mutant phenotype
18287528 GOA
NOT involved in protein exit from endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
18287528 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
12237308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED9 Protein Structure

EMP24_GP25L

EMP24_GP25L: emp24/gp25L/p24 family/GOLD (37 - 230)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 9

  • glycoprotein 25L2

TMED9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMED9 Q9BVK6 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
TMED9 Q9BVK6 TMEM60 Homo sapiens Q9H2L4
Y2H Array
32296183
Intra
TMED9 Q9BVK6 PTPN2 Homo sapiens P17706-1
Confocal
16595549
Intra
TMED9 Q9BVK6 PTPN2 Homo sapiens P17706-1
Y2H
16595549
Intra
TMED9 Q9BVK6 PTPN2 Homo sapiens P17706-1
Anti Tag CoIP
16595549
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMED9 Proteins

Cat. No. Product Name Accession Purity
HY-P76678 TMED9 Protein, Human (HEK293, His) Q9BVK6/NP_059980.2 (L38-R202) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76679 TMED9 Protein, Human (HEK293, Fc) Q9BVK6/NP_059980.2 (L38-R202) ≥ 85%, as determined by reducing SDS-PAGE.

TMED9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87109 TMED9 Antibody (YA6802) WB, IHC-P Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101374A AGN 192403 hydrochloride 99.96% Unkown
HY-101374 AGN 192403 / Unkown
HY-RS14640 TMED9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21790 Tmed9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28306 Tmed9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMED9 RGD RGD:1307627
Macaca mulatta TMED9 VGNC VGNC:110427
Mus musculus TMED9 MGD MGI:1914761
Others TMED9 NCBI