PPIA - peptidylprolyl isomerase A Gene

Also Known as CYPA; CYPH; HEL-S-69p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5478

About PPIA

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,796,681-44,803,117 (from NCBI)

This gene has 18 transcripts (splice variants), 235 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 161.2), colon (RPKM 155.9) and 25 other tissues.

Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV Proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

PPIA Products (2)

mRNA	Protein	Name
NM_001300981.2	NP_001287910.1	peptidyl-prolyl cis-trans isomerase A isoform 2
NM_021130.5	NP_066953.1	peptidyl-prolyl cis-trans isomerase A isoform 1

PPIA Protein Structure

Pro_isomerase

0
100
165 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase A	PPIase A

PPIA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	PPIA	P62937	gag	Human immunodeficiency virus	Q72497	X-Ray Diffraction	12730686
Cross	PPIA	P62937	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Y2H Pooling	22046132
Cross	PPIA	P62937	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Lumier	22046132
Intra	PPIA	P62937	HCRTR2	Homo sapiens	O43614	Validated Y2H	32814053
Intra	PPIA	P62937	HCRTR2	Homo sapiens	O43614	Y2H Array	32814053
Intra	PPIA	P62937	HCRTR2	Homo sapiens	O43614	Y2H Pooling	32814053
Intra	PPIA	P62937	CRK	Homo sapiens	P46108-1	ITC	26656091
Intra	PPIA	P62937	CRK	Homo sapiens	P46108-1	FRET	26656091
Intra	PPIA	P62937	CRK	Homo sapiens	P46108-1	NMR	26656091
Intra	PPIA	P62937	NCOR1	Homo sapiens	O75376	Y2H Array	32814053
Intra	PPIA	P62937	NCOR1	Homo sapiens	O75376	Validated Y2H	32814053
Intra	PPIA	P62937	NCOR1	Homo sapiens	O75376	Y2H Pooling	32814053
Intra	PPIA	P62937	RPS15	Homo sapiens	P62841	Validated Y2H	32814053
Intra	PPIA	P62937	RPS15	Homo sapiens	P62841	Y2H Array	32814053
Intra	PPIA	P62937	RPS15	Homo sapiens	P62841	Y2H Pooling	32814053
Intra	PPIA	P62937	PTPRN	Homo sapiens	Q16849	Y2H	16273344
Intra	PPIA	P62937	PTPRN	Homo sapiens	Q16849	Anti Tag CoIP	16273344
Intra	PPIA	P62937	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	PPIA	P62937	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	PPIA	P62937	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	PPIA	P62937	BSG	Homo sapiens	P35613	Affinity Chrom	15688292
Cross	PPIA	P62937	N	Human SARS coronavirus	P59595	SPR	15358143
Cross	PPIA	P62937	N	Human SARS coronavirus	P59595	Affinity Chrom	15688292
Cross	PPIA	P62937	N	Human SARS coronavirus	P59595	SPR	15688292
Intra	PPIA	P62937	KMT2D	Homo sapiens	O14686	FPS	39009827
Intra	PPIA	P62937	KMT2D	Homo sapiens	O14686	Phage Display	39009827

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70047	Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human (solution)	P62937-1 (M1-E165)	≥ 95%, as determined by reducing SDS-PAGE.

PPIA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80101	Cyclophilin A Antibody (YA481)	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Ogden Syndrome	OGDNS N-Terminal Acetyltransferase Deficiency NATD N-Alpha-Acetyltransferase X-Linked Malformation And Infantile Lethality Syndrome Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172209	PPIA-IN-1		96.90%	Unkown
HY-RS10946	PPIA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18045	Ppia Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24519	Ppia Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPIA	MGD	MGI:97749
Rattus norvegicus	PPIA	RGD	RGD:3372
Others	PPIA	NCBI