PPP2R2C - protein phosphatase 2 regulatory subunit Bgamma Gene
Also Known as PR52; PR55G; IMYPNO; IMYPNO1; B55gamma; B55-GAMMA
Species: Homo sapiens
About PPP2R2C
This gene has 9 transcripts (splice variants), 237 orthologues and 3 paralogues. Biased expression in brain (RPKM 39.0), endometrium (RPKM 11.7) and 4 other tissues.
Summary
The product of this gene belongs to the Phosphatase 2 regulatory subunit B family. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PPP2R2C Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001206994.2 | NP_001193923.1 | protein phosphatase 2, regulatory subunit B, gamma isoform c |
| NM_001206995.2 | NP_001193924.1 | protein phosphatase 2, regulatory subunit B, gamma isoform c |
| NM_001206996.2 | NP_001193925.1 | protein phosphatase 2, regulatory subunit B, gamma isoform d |
| NM_001363388.2 | NP_001350317.1 | protein phosphatase 2, regulatory subunit B, gamma isoform e |
| NM_020416.4 | NP_065149.2 | protein phosphatase 2, regulatory subunit B, gamma isoform a |
| NM_181876.3 | NP_870991.1 | protein phosphatase 2, regulatory subunit B, gamma isoform b |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein phosphatase 2, regulatory subunit B, gamma |
|
PPP2R2C Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP2R2C | Q9Y2T4 | PPP2CA | Homo sapiens | P67775 | 33961781 | |
|
Intra
|
PPP2R2C | Q9Y2T4 | PPP2CA | Homo sapiens | P67775 | 19156129 | |
|
Intra
|
PPP2R2C | Q9Y2T4 | PPP2CA | Homo sapiens | P67775 | 24126060 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Inflammatory Bowel Disease 3 |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | PPP2R2C | VGNC | VGNC:44909 |
| Macaca mulatta | PPP2R2C | VGNC | VGNC:76377 |
| Bos taurus | PPP2R2C | VGNC | VGNC:33257 |
| Rattus norvegicus | PPP2R2C | RGD | RGD:620920 |
| Mus musculus | PPP2R2C | MGD | MGI:2442660 |
| Felis catus | PPP2R2C | VGNC | VGNC:69013 |
| Others | PPP2R2C | NCBI |