Tgm2 - transglutaminase 2 Gene

Also Known as tTG; TgaseII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56083

Summary

Enables GTP binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Orthologous to human TGM2 (Transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgm2 Products (1)

mRNA Protein Name
NM_019386.3 NP_062259.3 protein-glutamine gamma-glutamyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
14970202 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12469910 RGD
enables phospholipase binding IPI
IPI: Inferred from physical interaction
16709602 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12054611 RGD
Biological Process GO Annotation Evidence References Source
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
15550691 RGD
involved in isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IDA
IDA: Inferred from direct assay
16341586 RGD
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7911253 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11073883 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
15471861 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
14970202 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7911253 RGD
located in cytosol IDA
IDA: Inferred from direct assay
11073883 RGD
located in nucleus IDA
IDA: Inferred from direct assay
11073883 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-glutamine gamma-glutamyltransferase 2

  • TGase 2

  • TGase II

  • glutamine gamma-glutamyltransferase 2

  • isopeptidase TGM2

  • protein G alpha(h)

  • protein G(h)

  • protein-glutamine deamidase TGM2

  • protein-glutamine dopaminyltransferase TGM2

  • protein-glutamine histaminyltransferase TGM2

  • protein-glutamine n

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128595 MT-4 Inhibitor 99.84% Unkown
HY-177133 Suvigletistat Inhibitor 99.82% Unkown
HY-181732 PROTAC TG2 Degrader-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgm2 NCBI NCBI:7052