Htra1 - HtrA serine peptidase 1 Gene

Also Known as L56; HTRA; Prss11; RSPP11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56213

Summary

Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; limb; reproductive system; sensory organ; and skin. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Htra1 Products (1)

mRNA Protein Name
NM_019564.3 NP_062510.2 serine protease HTRA1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14973287 MGI
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
15206957 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: Inferred from mutant phenotype
25446274 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
14973287 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
14973287 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
25446274 MGI
involved in proteolysis IDA
IDA: Inferred from direct assay
15206957 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease HTRA1

  • high-temperature requirement A serine peptidase 1

  • insulin-like growth factor binding protein 5 protease

  • protease, serine, 11 (Igf binding)

  • serine protease 11

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163690 HTRA1-IN-1 Inhibitor 95.28% Unkown
HY-RS06486 HTRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17551 Htra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24010 Htra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htra1 NCBI NCBI:5654