Arl6 - ADP-ribosylation factor-like 6 Gene

Also Known as BBS3; 1110018H24Rik; 2210411E14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56297

Summary

Predicted to enable GTP binding activity. Involved in protein localization to non-motile cilium. Acts upstream of or within several processes, including fat cell differentiation; protein transport from ciliary membrane to plasma membrane; and retina layer formation. Located in cytosol and membrane. Is expressed in several structures, including central nervous system; chondrocranium; embryo endoderm; forelimb bud; and node. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). [provided by Alliance of Genome Resources, Apr 2022]

Arl6 Products (2)

mRNA Protein Name
NM_001347244.1 NP_001334173.1 ADP-ribosylation factor-like protein 6 isoform 2
NM_019665.3 NP_062639.3 ADP-ribosylation factor-like protein 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10508919 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
22139371 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
22139371 MGI
involved in fat cell differentiation IEP
IEP: Inferred from expression pattern
17379567 MGI
involved in protein localization to non-motile cilium IDA
IDA: Inferred from direct assay
24939912 MGI
acts upstream of or within protein transport from ciliary membrane to plasma membrane IMP
IMP: Inferred from mutant phenotype
22139371 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
22139371 MGI
acts upstream of or within retina layer formation IMP
IMP: Inferred from mutant phenotype
20333246 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10508919 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22139371 MGI
located in membrane IDA
IDA: Inferred from direct assay
10508919 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 6

  • ADP-ribosylation-like 6

  • ADP-ribosylation-like factor homolog ARL6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00995 ARL6IP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00993 ARL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00994 ARL6IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00996 ARL6IP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00997 ARL6IP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18720 Arl6ip6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20693 Arl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21227 Arl6ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25207 Arl6ip6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27204 Arl6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27744 Arl6ip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arl6 NCBI NCBI:84100