IL36G - interleukin 36 gamma Gene

Homo sapiens

Also known as IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2

Gene ID: 56300 | Gene type: protein coding

About IL36G

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,978,006-112,985,658 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues and 7 paralogues. Biased expression in skin (RPKM 3.5) and esophagus (RPKM 1.0).

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus Infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]

IL36G Products(2)

mRNA	Protein	Name
NM_001278568.2	NP_001265497.1	interleukin-36 gamma isoform 2
NM_019618.4	NP_062564.1	interleukin-36 gamma isoform 1

IL36G Protein Structure

IL1

0
100
169 a.a.

Protein Preferred Names

Protein Names

interleukin-36 gamma

IL-1 related protein 2

Recombinant IL36G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70670	IL-36 gamma/IL-1F9 Protein, Human (152a.a)	Q9NZH8 (S18-D169)	≥95%
HY-P71863	IL-36 gamma/IL-1F9 Protein, Human (169a.a)	Q9NZH8 (M1-D169)	≥95%
HY-P71864	IL36G, Human (152a.a)	Q9NZH8 (S18-D169)	≥95%
HY-P71972	IL-36 gamma/IL-1F9 Protein, Human	Q9NZH8 (S18-D169)	≥95%
HY-P75861	IL-36 gamma/IL-1F9 Protein, Human (152a.a, His)	Q9NZH8 (S18-D169)	≥95%
HY-P75861AF	Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His)	Q9NZH8 (S18-D169)	≥95%

Related Diseases

Diseases

Alias

Acute Generalized Exanthematous Pustulosis

Agep	Pustular Drug Eruption
Toxic Pustuloderma

Psoriasis

Psoriasis 6

PSORS6	Psoriasis Susceptibility 6
Psoriasis 6, Susceptibility To

Psoriasis 5

PSORS5	Psoriasis Susceptibility 5
Psoriasis 5, Susceptibility To

Impetigo Herpetiformis

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Immunodeficiency, Common Variable, 9, Formerly	Cvid9, Formerly
Autoimmune Lymphoproliferative Syndrome Type Iii	Autoimmune Lymphoproliferative Syndrome 3
Cvid9	Immunodeficiency, Common Variable, 9
Type 3 Autoimmune Lymphoproliferative Syndrome	Immunodeficiency, Variable, Common, Type 9

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06761	IL36G Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL36G	MGD	MGI:2449929
Macaca mulatta	IL36G	VGNC	VGNC:73605
Bos taurus	IL36G	VGNC	VGNC:30158
Rattus norvegicus	IL36G	RGD	RGD:1563019
Others	IL36G	NCBI

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