IL36G - interleukin 36 gamma Gene

Also Known as IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56300

About IL36G

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,978,006-112,985,658 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues and 7 paralogues. Biased expression in skin (RPKM 3.5) and esophagus (RPKM 1.0).

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus Infection. This gene and eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]

IL36G Products (2)

mRNA Protein Name
NM_001278568.2 NP_001265497.1 interleukin-36 gamma isoform 2
NM_019618.4 NP_062564.1 interleukin-36 gamma isoform 1

IL36G Protein Structure

IL1

IL1: Interleukin-1 / 18 (70 - 158)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

interleukin-36 gamma

  • IL-1 related protein 2

Recombinant IL36G Proteins

Cat. No. Product Name Accession Purity
HY-P70670 IL-36 gamma/IL-1F9 Protein, Human Q9NZH8-1 (S18-D169) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75861 IL-36 gamma/IL-1F9 Protein, Human (His) Q9NZH8-1 (S18-D169) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75861AF Animal-Free IL-36 gamma/IL-1F9 Protein, Human (His) Q9NZH8-1 (S18-D169) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Acute Generalized Exanthematous Pustulosis

  • Agep

  • Pustular Drug Eruption

  • Toxic Pustuloderma
Psoriasis
Psoriasis 6

  • PSORS6

  • Psoriasis Susceptibility 6

  • Psoriasis 6, Susceptibility To
Psoriasis 5

  • PSORS5

  • Psoriasis Susceptibility 5

  • Psoriasis 5, Susceptibility To
Impetigo Herpetiformis
Psoriasis 14, Pustular

  • Generalized Pustular Psoriasis

  • Gpp

  • Ditra

  • Acrodermatitis Continua Of Hallopeau

  • Palmoplantar Pustulosis

  • PSORS14

  • Interleukin 36 Receptor Antagonist Deficiency

  • Psorp

  • Pustular Psoriasis 14

  • Deficiency Of Il-36r Antagonist

  • Acute Generalised Pustular Psoriasis

  • Deficiency Of The Interleukin-36 Receptor Antagonist

  • Generalized Pustular Psoriasis Of Von Zumbusch

  • Von Zumbusch Psoriasis

  • Deficiency Of Il-36ra

  • Psoriasis, Pustular, Generalized

  • Psoriasis, Pustular, Type 14

  • Pustulosis Of Palms And Soles

  • Acute Generalized Pustular Psoriasis

  • Palmoplantar Pustular Psoriasis

  • Pustulosis Palmaris Et Plantaris

  • Ppp - [Palmoplantar Pustulosis]

  • Pustular Psoriasis Of The Palms And Soles

  • Pustular Bacterid
Autoimmune Lymphoproliferative Syndrome, Type Iii

  • ALPS3

  • Autoimmune Lymphoproliferative Syndrome Type 3

  • Immunodeficiency, Common Variable, 9, Formerly

  • Cvid9, Formerly

  • Autoimmune Lymphoproliferative Syndrome Type Iii

  • Autoimmune Lymphoproliferative Syndrome 3

  • Cvid9

  • Immunodeficiency, Common Variable, 9

  • Type 3 Autoimmune Lymphoproliferative Syndrome

  • Immunodeficiency, Variable, Common, Type 9
Pityriasis Rubra Pilaris

  • PRP

  • Devergie'S Disease

  • Prp - [Pityriasis Rubra Pilaris]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06761 IL36G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17831 Il36g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24299 Il36g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL36G MGD MGI:2449929
Macaca mulatta IL36G VGNC VGNC:73605
Bos taurus IL36G VGNC VGNC:30158
Rattus norvegicus IL36G RGD RGD:1563019
Others IL36G NCBI