Diaph3 - diaphanous related formin 3 Gene

Also Known as Dia2; Drf3; Diap3; p134MDia2; 4930417P13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56419

Summary

Predicted to enable actin binding activity and small GTPase binding activity. Involved in actin filament polymerization. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; gonad; spleen; and vibrissa. Used to study autosomal dominant auditory neuropathy 1 and congenital dyserythropoietic anemia. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3). [provided by Alliance of Genome Resources, Apr 2022]

Diaph3 Products (1)

mRNA Protein Name
NM_019670.2 NP_062644.1 protein diaphanous homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
16556604 MGI
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
16556604 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
18458159 MGI
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
18458159 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15976449 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16556604 MGI
enables protein homodimerization activity IMP
IMP: Inferred from mutant phenotype
18458159 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin crosslink formation IDA
IDA: Inferred from direct assay
18835565 MGI
acts upstream of or within actin crosslink formation IMP
IMP: Inferred from mutant phenotype
18835565 MGI
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
33036023 MGI
acts upstream of or within actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
18264091 MGI
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
28255013 MGI
acts upstream of or within actin filament polymerization IDA
IDA: Inferred from direct assay
23034183 MGI
involved in actin filament polymerization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within actin filament polymerization IMP
IMP: Inferred from mutant phenotype
23034183 MGI
acts upstream of or within actin nucleation IDA
IDA: Inferred from direct assay
21278336 MGI
acts upstream of or within autophagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
33036023 MGI
acts upstream of or within cell projection organization IDA
IDA: Inferred from direct assay
23441200 MGI
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
27848932 MGI
acts upstream of or within cytokinesis IDA
IDA: Inferred from direct assay
20660154 MGI
acts upstream of or within cytokinesis IMP
IMP: Inferred from mutant phenotype
24239357 MGI
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
23558171 MGI
acts upstream of or within endosomal transport IMP
IMP: Inferred from mutant phenotype
33036023 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
26471482 MGI
acts upstream of or within erythrocyte enucleation IMP
IMP: Inferred from mutant phenotype
18264091 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
32576838 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
21278336 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
32576838 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
27848932 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
24239357 MGI
acts upstream of or within inner ear receptor cell differentiation IDA
IDA: Inferred from direct assay
23441200 MGI
acts upstream of or within integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
32576838 MGI
acts upstream of or within macrophage differentiation IMP
IMP: Inferred from mutant phenotype
26471482 MGI
acts upstream of or within microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
24069443 MGI
acts upstream of or within microtubule polymerization IDA
IDA: Inferred from direct assay
18458159 MGI
acts upstream of or within microtubule polymerization IMP
IMP: Inferred from mutant phenotype
18458159 MGI
acts upstream of or within negative regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
18458159 MGI
acts upstream of or within negative regulation of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
18458159 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
27848932 MGI
acts upstream of or within organelle organization IMP
IMP: Inferred from mutant phenotype
33036023 MGI
acts upstream of or within podosome assembly IMP
IMP: Inferred from mutant phenotype
15976449 MGI
acts upstream of or within protein-containing complex remodeling IMP
IMP: Inferred from mutant phenotype
33036023 MGI
acts upstream of or within regulation of deacetylase activity IDA
IDA: Inferred from direct assay
15976449 MGI
acts upstream of or within sensory perception of sound IDA
IDA: Inferred from direct assay
23441200 MGI
acts upstream of or within spindle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
27848932 MGI
Cellular Component GO Annotation Evidence References Source
part of ESCRT I complex IMP
IMP: Inferred from mutant phenotype
33036023 MGI
is active in actin filament bundle IDA
IDA: Inferred from direct assay
16556604 MGI
is active in cleavage furrow IDA
IDA: Inferred from direct assay
20660154 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19117945 MGI
part of filamentous actin IDA
IDA: Inferred from direct assay
18835565 MGI
part of filamentous actin IMP
IMP: Inferred from mutant phenotype
18835565 MGI
is active in microtubule organizing center IDA
IDA: Inferred from direct assay
24069443 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19117945 MGI
is active in ribbon synapse IDA
IDA: Inferred from direct assay
23441200 MGI
is active in spindle pole IDA
IDA: Inferred from direct assay
24069443 MGI
is active in stereocilia tip-link density IDA
IDA: Inferred from direct assay
23441200 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein diaphanous homolog 3

Diaph3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Diaph3 Q9Z207 Abi1 Mus musculus Q8CBW3
Pull Down
18044991
Intra
Diaph3 Q9Z207 Abi1 Mus musculus Q8CBW3
Anti Bait CoIP
18044991
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168969 AA-BR-157 96.47% Unkown
HY-RS03765 DIAPH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21845 Diaph3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28361 Diaph3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Diaph3 NCBI NCBI:81624