Abi1 - abl interactor 1 Gene

Also Known as E3B1; NAP1; abi-1; Ssh3bp1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11308

Summary

Enables protein tyrosine kinase activator activity and signaling adaptor activity. Acts upstream of or within megakaryocyte development; plasma membrane bounded cell projection morphogenesis; and somitogenesis. Located in lamellipodium and neuron projection. Part of SCAR complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Abi1 Products (12)

mRNA Protein Name
NM_001077190.3 NP_001070658.1 abl interactor 1 isoform 1
NM_001077192.3 NP_001070660.1 abl interactor 1 isoform 4
NM_001077193.3 NP_001070661.1 abl interactor 1 isoform 5
NM_001331043.1 NP_001317972.1 abl interactor 1 isoform 6
NM_001331044.1 NP_001317973.1 abl interactor 1 isoform 7
NM_001331045.1 NP_001317974.1 abl interactor 1 isoform 8
NM_001377510.1 NP_001364439.1 abl interactor 1 isoform 9
NM_001377511.1 NP_001364440.1 abl interactor 1 isoform 10
NM_001377512.1 NP_001364441.1 abl interactor 1 isoform 11
NM_001377513.1 NP_001364442.1 abl interactor 1 isoform 12
NM_007380.4 NP_031406.2 abl interactor 1 isoform 3
NM_145994.3 NP_666106.1 abl interactor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
9010225 MGI
enables protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
12672821 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
12672821 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within dendrite morphogenesis IDA
IDA: Inferred from direct assay
25297099 MGI
acts upstream of or within lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
17664349 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
17664349 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
15755804 MGI
Cellular Component GO Annotation Evidence Referencias Source
part of SCAR complex IDA
IDA: Inferred from direct assay
12672821 MGI
located in cell leading edge IDA
IDA: Inferred from direct assay
16831833 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12672821 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21795692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

abl interactor 1

  • abelson interactor 1

  • ablphilin-1

  • eps8 SH3 domain-binding protein

  • eps8 binding protein

  • spectrin SH3 domain binding protein 1

Abi1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
Abi1 Q8CBW3 Eps8 Mus musculus Q08509
CoIP
9010225
Intra
Abi1 Q8CBW3 Sos2 Mus musculus Q02384
Affinity Chrom
11003655
Intra
Abi1 Q8CBW3 Wasf2 Mus musculus Q8BH43
Anti Bait CoIP
18044991
Intra
Abi1 Q8CBW3 Wasf2 Mus musculus Q8BH43
Pull Down
20697350
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00098 ABI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19872 Abi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26371 Abi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abi1 NCBI NCBI:10006