Kcnip3 - Kv channel interacting protein 3, calsenilin Gene

Also Known as Csen; DREAM; KChIP3; 4933407H12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56461

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding activity; and transcription cis-regulatory region binding activity. Involved in protein localization to plasma membrane; regulation of potassium ion transmembrane transport; and response to magnesium ion. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of transcription by RNA polymerase II; and sensory perception of pain. Located in cytosol and nucleus. Part of protein-DNA complex and voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and spinal cord. Orthologous to human KCNIP3 (potassium voltage-gated channel interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnip3 Products (3)

mRNA	Protein	Name
NM_001111331.1	NP_001104801.1	calsenilin isoform b precursor
NM_001291005.1	NP_001277934.1	calsenilin isoform c
NM_019789.4	NP_062763.2	calsenilin isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11792319	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11792319	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11792319	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11792319	MGI
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	15746104	MGI
enables calcium ion binding	IPI IPI: Inferred from physical interaction	15746104	MGI
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15746104	MGI
enables core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15746104	MGI
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	15746104	MGI
enables magnesium ion binding	IPI IPI: Inferred from physical interaction	15746104	MGI
enables potassium channel regulator activity	IMP IMP: Inferred from mutant phenotype	20943905	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17189291	MGI
enables protein homodimerization activity	EXP EXP: Inferred from Experiment	15746104	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within behavioral response to pain	IMP IMP: Inferred from mutant phenotype	14534243	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11792319	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	22311982	MGI
acts upstream of or within regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	17189291	MGI
involved in regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	20943905	MGI
involved in response to magnesium ion	IMP IMP: Inferred from mutant phenotype	15746104	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	11792319	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	11792319	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	17189291	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17189291	MGI
part of protein-DNA complex	IMP IMP: Inferred from mutant phenotype	15746104	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19713751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calsenilin	A-type potassium channel modulatory protein 3 DRE-antagonist modulator calsenilin, presenilin binding protein, EF hand transcription factor calsenilin/KChIP3 T+ calsenilin/KChIP3 T- downstream regulatory element antagonist T+ downstream regulatory e

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07134	KCNIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20559	Kcnip3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27068	Kcnip3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnip3	NCBI	NCBI:30818