Anxa2 - annexin A2 Gene

Also Known as ANX2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56611

Summary

Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including AnxA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]

Anxa2 Products (1)

mRNA Protein Name
NM_019905.1 NP_063970.1 annexin A2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bone sialoprotein binding IPI
IPI: Inferred from physical interaction
23525114 RGD
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
14734570 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
18332131 RGD
Biological Process GO Annotation Evidence References Source
involved in body fluid secretion IMP
IMP: Inferred from mutant phenotype
18332131 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
19193640 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19193640 RGD
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
19193640 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
9022675 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
19193640 RGD
located in cytosol IDA
IDA: Inferred from direct assay
14499952 RGD
located in macropinosome IDA
IDA: Inferred from direct assay
19193640 RGD
located in membrane IDA
IDA: Inferred from direct assay
23525114 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14734570 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
23525114 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15823548 RGD
located in ruffle IDA
IDA: Inferred from direct assay
19193640 RGD
located in vesicle IDA
IDA: Inferred from direct assay
19193640 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

annexin A2

  • PAP-IV

  • annexin-2

  • calpactin I heavy chain

  • calpactin-1 heavy chain

  • chromobindin-8

  • lipocortin II

  • p36

  • placental anticoagulant protein IV

  • protein I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141644 PY-60 Activator 99.42% Unkown
HY-P2333 LCKLSL Inhibitor 99.26% Unkown
HY-P2333A LCKLSL hydrochloride Inhibitor 98.05% Unkown
HY-169212 I194496 Inhibitor 98.52% Unkown
HY-RS00761 ANXA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16855 Anxa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176548 PY-PAP / Unkown
HY-RS00762 ANXA2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23296 Anxa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Anxa2 NCBI NCBI:302