Gsk3b - glycogen synthase kinase 3 beta Gene

Also Known as GSK3; GSK-3; GSK-3beta; 7330414F15Rik; 8430431H08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56637

Summary

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of nitrogen compound metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3b Products (2)

mRNA Protein Name
NM_001347232.1 NP_001334161.1 glycogen synthase kinase-3 beta isoform 2
NM_019827.7 NP_062801.1 glycogen synthase kinase-3 beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12874278 MGI
enables dynein complex binding IPI
IPI: Inferred from physical interaction
28057765 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9554852 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14730361 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
22899650 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12805290 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16543145 MGI
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
15192701 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ER overload response IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
23074275 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10894547 MGI
acts upstream of positive effect autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
21047779 MGI
acts upstream of axon extension IGI
IGI: Inferred from genetic interaction
24623780 MGI
acts upstream of or within axonogenesis IGI
IGI: Inferred from genetic interaction
18716223 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15282335 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16815997 MGI
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
17986005 MGI
involved in cellular response to glucocorticoid stimulus IGI
IGI: Inferred from genetic interaction
20371704 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IDA
IDA: Inferred from direct assay
21072211 MGI
involved in cellular response to interleukin-3 IDA
IDA: Inferred from direct assay
16543145 MGI
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
20123978 MGI
involved in extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
20371704 MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
16543145 MGI
acts upstream of or within fat cell differentiation IDA
IDA: Inferred from direct assay
12502791 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
28057765 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
23028846 MGI
involved in meiosis I IMP
IMP: Inferred from mutant phenotype
29228573 MGI
acts upstream of or within myoblast fusion IDA
IDA: Inferred from direct assay
15282335 MGI
acts upstream of or within myoblast fusion IGI
IGI: Inferred from genetic interaction
15282335 MGI
acts upstream of or within myotube differentiation IGI
IGI: Inferred from genetic interaction
15282335 MGI
involved in negative regulation of TOR signaling IGI
IGI: Inferred from genetic interaction
26160071 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10894547 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
12154096 MGI
acts upstream of or within negative regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
11782539 MGI
involved in negative regulation of glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
31553910 MGI
acts upstream of or within negative regulation of neuron maturation IGI
IGI: Inferred from genetic interaction
23015435 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
23015435 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
23015435 MGI
involved in negative regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
28057765 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17986005 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
20123978 MGI
involved in peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
16537926 MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
29228573 MGI
involved in phosphorylation IMP
IMP: Inferred from mutant phenotype
17182001 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
22539723 MGI
involved in positive regulation of autophagy IGI
IGI: Inferred from genetic interaction
26160071 MGI
acts upstream of or within positive regulation of axon extension IGI
IGI: Inferred from genetic interaction
24623780 MGI
involved in positive regulation of cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
24974728 MGI
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25860027 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
20371704 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24974728 MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
16543145 MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17986005 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
22660580 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
19141611 MGI
involved in positive regulation of protein localization to cilium IMP
IMP: Inferred from mutant phenotype
25860027 MGI
acts upstream of or within positive regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22064483 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23015435 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21047779 MGI
acts upstream of or within protein export from nucleus IDA
IDA: Inferred from direct assay
11782539 MGI
acts upstream of or within protein localization to microtubule IGI
IGI: Inferred from genetic interaction
18716223 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12432063 MGI
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
19141611 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16543145 MGI
acts upstream of or within re-entry into mitotic cell cycle IDA
IDA: Inferred from direct assay
12502791 MGI
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12154096 MGI
acts upstream of or within regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18824542 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
28556462 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
28556462 MGI
involved in regulation of microtubule-based process IDA
IDA: Inferred from direct assay
21295697 MGI
acts upstream of or within regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
24227739 MGI
acts upstream of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22064483 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23015435 MGI
Cellular Component GO Annotation Evidence References Source
part of Wnt signalosome IDA
IDA: Inferred from direct assay
22899650 MGI
part of beta-catenin destruction complex IDA
IDA: Inferred from direct assay
10318824 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12502791 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
12805290 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20111716 MGI
located in growth cone IDA
IDA: Inferred from direct assay
12805290 MGI
is active in meiotic spindle IDA
IDA: Inferred from direct assay
29228573 MGI
located in membrane-bounded organelle IDA
IDA: Inferred from direct assay
12805290 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
12805290 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12502791 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20890042 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20111716 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
21709260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycogen synthase kinase-3 beta

  • serine/threonine-protein kinase GSK3B

Gsk3b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gsk3b Q9WV60 Epm2a Mus musculus Q9WUA5
Anti Bait CoIP
16959610
Intra
Gsk3b Q9WV60 Ctnnb1 Mus musculus Q02248
Protein Kinase Assay
19107203
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Gsk3b Proteins

Cat. No. Product Name Accession Purity
HY-P73090 GSK-3 beta Protein, Mouse (Active, sf9, His) Q9WV60 (M1-T420) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0657 Pinoresinol Diglucoside 99.84% Unkown
HY-112388 GSK-3b Inhibitor XI Inhibitor 99.10% Unkown
HY-RS05865 GSK3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183955 GNF7156 Inhibitor / Unkown
HY-RS17170 Gsk3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23620 Gsk3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsk3b NCBI NCBI:2932