EIF5A2 - eukaryotic translation initiation factor 5A2 Gene

Also Known as EIF-5A2; eIF5AII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56648

About EIF5A2

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,888,418-170,908,637 (from NCBI)

This gene has 5 transcripts (splice variants), 171 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 2.3) and 25 other tissues.

Summary

Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A2 Products (1)

mRNA Protein Name
NM_020390.6 NP_065123.1 eukaryotic translation initiation factor 5A-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14622290 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5A2 Protein Structure

eIF-5a

eIF-5a: Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold (83 - 150)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5A-2

  • eIF-5A-2

EIF5A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF5A2 Q9GZV4 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
EIF5A2 Q9GZV4 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
EIF5A2 Q9GZV4 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
EIF5A2 Q9GZV4 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
EIF5A2 Q9GZV4 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
25416956
Intra
EIF5A2 Q9GZV4 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
EIF5A2 Q9GZV4 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
EIF5A2 Q9GZV4 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
EIF5A2 Q9GZV4 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
Intra
EIF5A2 Q9GZV4 DHPS Homo sapiens P49366
Y2H Array
32296183
Intra
EIF5A2 Q9GZV4 DHPS Homo sapiens P49366
Anti Tag CoIP
33961781
Intra
EIF5A2 Q9GZV4 DHPS Homo sapiens P49366
Y2H Prey Pooling
25416956
Intra
EIF5A2 Q9GZV4 DHPS Homo sapiens P49366
Validated Y2H
25416956
Intra
EIF5A2 Q9GZV4 DHPS Homo sapiens P49366
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF5A2 Proteins

Cat. No. Product Name Accession Purity
HY-P70910 EIF5A2 Protein, Human (His) Q9GZV4 (M1-K153) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04287 EIF5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19060 Eif5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25550 Eif5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EIF5A2 VGNC VGNC:40293
Rattus norvegicus EIF5A2 RGD RGD:1306196
Felis catus EIF5A2 VGNC VGNC:61798
Bos taurus EIF5A2 VGNC VGNC:28419
Macaca mulatta EIF5A2 VGNC VGNC:72198
Mus musculus EIF5A2 MGD MGI:1933735
Others EIF5A2 NCBI