PSG1 - pregnancy specific beta-1-glycoprotein 1 Gene

Also Known as SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5669

About PSG1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,866,464-42,879,713 (from NCBI)

This gene has 11 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 224.3).

Summary

The human placenta is a multihormonal endocrine organ that produces Hormones, Enzymes, and Other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

PSG1 Products (5)

mRNA Protein Name
NM_001184825.2 NP_001171754.1 pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor
NM_001184826.2 NP_001171755.1 pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor
NM_001297773.2 NP_001284702.1 pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor
NM_001330524.2 NP_001317453.1 pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor
NM_006905.3 NP_008836.2 pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSG1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (36 - 133)

Ig_2

Ig_2: Immunoglobulin domain (148 - 234)

Ig_2

Ig_2: Immunoglobulin domain (252 - 328)

Ig_2

Ig_2: Immunoglobulin domain (335 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

pregnancy-specific beta-1-glycoprotein 1

  • CD66 antigen-like family member F

PSG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSG1 P11464 OGT Homo sapiens O15294
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSG1 Proteins

Cat. No. Product Name Accession Purity
HY-P72486 PSG1 Protein, Human (HEK293, His) P11464-1/NP_001171754.1 (Q35-P419) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole

  • Gestational Trophoblastic Disease

  • Complete Hydatidiform Mole

  • Hydm

  • HYDM1

  • Chm

  • Molar Pregnancy

  • Hydatidiform Mole, Complete

  • Hydatid Mole

  • Complete Molar Pregnancy

  • Mole, Hydatidiform, Recurrent, Type 1

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 2

  • Classical Hydatidiform Mole
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Ectopic Pregnancy

  • Eccyesis

  • Pregnancy Ectopic

  • Pregnancy, Ectopic

  • Ectopic Pregnancies

  • Extrauterine Gestation Or Pregnancy

  • Extrauterine Pregnancy

  • Ep - [Ectopic Pregnancy]

  • Ectopic Mole

  • Aborted Ectopic Pregnancy

  • Ruptured Ectopic Pregnancy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11279 PSG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11281 PSG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11286 PSG7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11287 PSG8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown