ZNFX1 - zinc finger NFX1-type containing 1 Gene

Also Known as IMD91

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57169

About ZNFX1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,245,900-49,278,057 (from NCBI)

This gene has 6 transcripts (splice variants), 213 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung (RPKM 11.1), spleen (RPKM 10.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in heterochromatin assembly by small RNA. Predicted to be part of nuclear RNA-directed RNA polymerase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNFX1 Products (1)

mRNA Protein Name
NM_021035.3 NP_066363.1 NFX1-type zinc finger-containing protein 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
33876776 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
33872655 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
33876776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNFX1 Protein Structure

AAA_11

AAA_11: AAA domain (597 - 1038)

AAA_12

AAA_12: AAA domain (1051 - 1234)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1918 a.a.
Protein Preferred Names Protein Names

NFX1-type zinc finger-containing protein 1

Related Diseases

Diseases Alias
Immunodeficiency 91 And Hyperinflammation

  • IMD91
Acromesomelic Dysplasia 2b

  • Fibular Hypoplasia And Complex Brachydactyly

  • Du Pan Syndrome

  • AMD2B

  • Dupans

  • Acromesomelic Dysplasia-2b

  • Fibular Aplasia-Complex Brachydactyly Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16180 ZNFX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZNFX1 VGNC VGNC:37357
Macaca mulatta ZNFX1 VGNC VGNC:79794
Rattus norvegicus ZNFX1 RGD RGD:1306344
Canis familiaris ZNFX1 VGNC VGNC:48834
Mus musculus ZNFX1 MGD MGI:2138982
Felis catus ZNFX1 VGNC VGNC:67365