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Cnr2 - cannabinoid receptor 2 Gene

Also Known as CB2; CB-2; CB2C; CNR2C

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 57302

About Cnr2

Primary_assembly 5: 148,125,604-148,151,548 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 196 orthologues, 18 paralogues and is associated with 28 phenotypes. Biased expression in Spleen (RPKM 23.), Lung (RPKM 25.2) and 5 other tissues.

Summary

Enables Cannabinoid Receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (Cannabinoid Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnr2 Products (3)

mRNA	Protein	Name
NM_001164143.3	NP_001157615.1	cannabinoid receptor 2 isoform 1
NM_001164142.3	NP_001157614.1	cannabinoid receptor 2 isoform 1
NM_020543.4	NP_065418.3	cannabinoid receptor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	10688601	RGD
enables cannabinoid receptor activity	IDA IDA: Inferred from direct assay	10688601	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12084572	RGD
involved in negative regulation of action potential	IMP IMP: Inferred from mutant phenotype	19616018	RGD
involved in negative regulation of mast cell activation	IDA IDA: Inferred from direct assay	18552882	RGD
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	18561998	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	19616018	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	20067581	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	18483180	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	18991891	RGD
located in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	18798269	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18991891	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18991892	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cnr2 Protein Structure

7tmA_CB2

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
cannabinoid receptor 2	CB2 receptor cannabinoid receptor 2 (macrophage) peripheral cannabinoid receptor rCB2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153169	6PPD-Q	Inhibitor	99.77%	Unkown
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-107713	PPDA	Antagonist	98.0%	Unkown
HY-RS02917	CNR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02918	Cnr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02919	Cnr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnr2	NCBI	NCBI:1269