Cnr2 - cannabinoid receptor 2 Gene

Rattus norvegicus

Also known as CB2; CB-2; CB2C; CNR2C

Gene ID: 57302 | Gene type: protein coding

About Cnr2

Primary_assembly 5: 148,125,604-148,151,548 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 196 orthologues, 18 paralogues and is associated with 28 phenotypes. Biased expression in Spleen (RPKM 23.), Lung (RPKM 25.2) and 5 other tissues.

Summary

Enables Cannabinoid Receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (Cannabinoid Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnr2 Products(3)

mRNA	Protein	Name
NM_001164143.3	NP_001157615.1	cannabinoid receptor 2 isoform 1
NM_001164142.3	NP_001157614.1	cannabinoid receptor 2 isoform 1
NM_020543.4	NP_065418.3	cannabinoid receptor 2 isoform 2

Cnr2 Protein Structure

7tmA_CB2

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

cannabinoid receptor 2

CB2 receptor	cannabinoid receptor 2 (macrophage)
peripheral cannabinoid receptor	rCB2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15703	QNZ46	Antagonist	98.80%	Unkown
HY-107713	PPDA	Antagonist	/	Unkown
HY-RS02917	CNR2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS02918	Cnr2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS02919	Cnr2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnr2	NCBI	NCBI:1269

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