PTGER1 - prostaglandin E receptor 1 Gene

Also Known as EP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5731

About PTGER1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,472,466-14,475,354 (from NCBI)

This gene has 1 transcript (splice variant), 238 orthologues and 7 paralogues. Biased expression in kidney (RPKM 4.8), spleen (RPKM 1.1) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to Bacterial endotoxin. [provided by RefSeq, Jul 2008]

PTGER1 Products (1)

mRNA Protein Name
NM_000955.3 NP_000946.2 prostaglandin E2 receptor EP1 subtype

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin E receptor activity IDA
IDA: Inferred from direct assay
8253813 GOA
Biological Process GO Annotation Evidence References Source
involved in response to prostaglandin E IDA
IDA: Inferred from direct assay
8253813 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
8253813 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGER1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 351)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

prostaglandin E2 receptor EP1 subtype

  • PGE receptor, EP1 subtype

Related Diseases

Diseases Alias
Tinea Barbae

  • Dermatophytosis Of Beard
Primary Hypertrophic Osteoarthropathy

  • Pachydermoperiostosis Syndrome

  • Osteoarthropathy, Primary Hypertrophic

  • Pachydermoperiostosis Of Nail

  • Idiopathic Hypertrophic Osteoarthropathy

  • Pho
Ovarian Seromucinous Carcinoma

  • Mixed Epithelial Carcinoma Of Ovary

  • Ovary Mixed Epithelial Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11375 PTGER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21916 Ptger1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28433 Ptger1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTGER1 VGNC VGNC:102669
Rattus norvegicus PTGER1 RGD RGD:3434
Mus musculus PTGER1 MGD MGI:97793
Canis familiaris PTGER1 VGNC VGNC:45142
Bos taurus PTGER1 VGNC VGNC:33501