2. Gene
  3. PTGER1 - prostaglandin E receptor 1 Gene

PTGER1 - prostaglandin E receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EP1

Gene ID: 5731 | Gene type: protein coding

About PTGER1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,472,466-14,475,354 (from NCBI)

This gene has 1 transcript (splice variant), 238 orthologues and 7 paralogues. Biased expression in kidney (RPKM 4.8), spleen (RPKM 1.1) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to Bacterial endotoxin. [provided by RefSeq, Jul 2008]

PTGER1 Products(1)

mRNA Protein Name
NM_000955.3 NP_000946.2 prostaglandin E2 receptor EP1 subtype

PTGER1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 351)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

prostaglandin E2 receptor EP1 subtype

PGE receptor, EP1 subtype

Related Diseases

Diseases Alias
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Idiopathic Hypertrophic Osteoarthropathy

Pho
Ovarian Seromucinous Carcinoma

Mixed Epithelial Carcinoma Of Ovary

Ovary Mixed Epithelial Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11375 PTGER1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTGER1 VGNC VGNC:102669
Rattus norvegicus PTGER1 RGD RGD:3434
Mus musculus PTGER1 MGD MGI:97793
Canis familiaris PTGER1 VGNC VGNC:45142
Bos taurus PTGER1 VGNC VGNC:33501