CASKIN2 - CASK interacting protein 2 Gene

Also Known as ANKS5B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57513

About CASKIN2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,500,261-75,515,537 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 13.1), lung (RPKM 12.8) and 24 other tissues.

Summary

This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

CASKIN2 Products (2)

mRNA Protein Name
NM_001142643.3 NP_001136115.1 caskin-2 isoform b
NM_020753.5 NP_065804.2 caskin-2 isoform a

CASKIN2 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (7 - 110)

Ank_4

Ank_4: Ankyrin repeats (many copies) (118 - 168)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (185 - 251)

SH3_2

SH3_2: Variant SH3 domain (286 - 344)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (490 - 549)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (561 - 619)

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  • 1202 a.a.
Protein Preferred Names Protein Names

caskin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01940 CASKIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21992 Caskin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28509 Caskin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CASKIN2 RGD RGD:1309738
Canis familiaris CASKIN2 VGNC VGNC:38731
Mus musculus CASKIN2 MGD MGI:2157062
Macaca mulatta CASKIN2 VGNC VGNC:70577
Felis catus CASKIN2 VGNC VGNC:60378
Bos taurus CASKIN2 VGNC VGNC:26778
Others CASKIN2 NCBI