PDP2 - pyruvate dehydrogenase phosphatase catalytic subunit 2 Gene

Also Known as PPM2B; PDPC 2; PPM2C2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57546

About PDP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,880,515-66,891,101 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 16 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.0) and 25 other tissues.

Summary

This gene is a mitochondrial protein that functions as a Phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]

PDP2 Products (8)

mRNA Protein Name
NM_001329928.2 NP_001316857.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329929.2 NP_001316858.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329930.2 NP_001316859.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329931.2 NP_001316860.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329932.2 NP_001316861.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329933.2 NP_001316862.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329934.2 NP_001316863.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_020786.4 NP_065837.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

PDP2 Protein Structure

PP2C

PP2C: Protein phosphatase 2C (227 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

  • protein phosphatase 2C, magnesium-dependent, catalytic subunit 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10286 PDP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDP2 VGNC VGNC:75896
Bos taurus PDP2 VGNC VGNC:32714
Mus musculus PDP2 MGD MGI:1918878
Felis catus PDP2 VGNC VGNC:64094
Rattus norvegicus PDP2 RGD RGD:628812
Canis familiaris PDP2 VGNC VGNC:44389
Others PDP2 NCBI