KLHL14 - kelch like family member 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57565

About KLHL14

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,672,673-32,773,023 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 54 paralogues. Biased expression in thyroid (RPKM 4.4), spleen (RPKM 2.8) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]

KLHL14 Products (1)

mRNA Protein Name
NM_020805.3 NP_065856.1 kelch-like protein 14

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19535332 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL14 Protein Structure

BTB

BTB: BTB/POZ domain (24 - 65)

BTB

BTB: BTB/POZ domain (116 - 180)

BACK

BACK: BTB And C-terminal Kelch (210 - 279)

Kelch_1

Kelch_1: Kelch motif (363 - 411)

Kelch_1

Kelch_1: Kelch motif (414 - 458)

Kelch_1

Kelch_1: Kelch motif (461 - 505)

Kelch_1

Kelch_1: Kelch motif (560 - 602)

  • 0
  • 100
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  • 400
  • 500
  • 628 a.a.
Protein Preferred Names Protein Names

kelch-like protein 14

  • kelch-like 14

Related Diseases

Diseases Alias
Mcd Diffuse Large B-Cell Lymphoma

  • Mcd Dlbcl

  • Doid:0081066
Photoallergic Dermatitis

  • Dermatitis, Photoallergic

  • Photoallergic Contact Dermatitis

  • Photoallergic Eczema

  • Photo-Allergic Contact Eczema
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07358 KLHL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KLHL14 RGD RGD:1566178
Bos taurus KLHL14 VGNC VGNC:30644
Macaca mulatta KLHL14 VGNC VGNC:82171
Canis familiaris KLHL14 VGNC VGNC:42450
Felis catus KLHL14 VGNC VGNC:63144
Mus musculus KLHL14 MGD MGI:1921249
Others KLHL14 NCBI