2. Gene
  3. USP36 - ubiquitin specific peptidase 36 Gene

USP36 - ubiquitin specific peptidase 36 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DUB1

Gene ID: 57602 | Gene type: protein coding

About USP36

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,787,381-78,841,439 (from NCBI)

This gene has 25 transcripts (splice variants), 201 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 or Ubiquitin-Specific Protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of Autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

USP36 Products(13)

mRNA Protein Name
NM_001321291.2 NP_001308220.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385169.1 NP_001372098.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 1
NM_001385170.1 NP_001372099.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385171.1 NP_001372100.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385172.1 NP_001372101.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385173.1 NP_001372102.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385174.1 NP_001372103.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385175.1 NP_001372104.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385176.1 NP_001372105.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385177.1 NP_001372106.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385178.1 NP_001372107.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385179.1 NP_001372108.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 4
NM_001385180.1 NP_001372109.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 5

USP36 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (122 - 420)

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  • 1123 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 36

deubiquitinating enzyme 36

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15547 USP36 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP36 VGNC VGNC:52844
Felis catus USP36 VGNC VGNC:66882
Mus musculus USP36 MGD MGI:1919594
Canis familiaris USP36 VGNC VGNC:55014
Macaca mulatta USP36 VGNC VGNC:79219
Rattus norvegicus USP36 RGD RGD:1309937