USP36 - ubiquitin specific peptidase 36 Gene

Also Known as DUB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57602

About USP36

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,787,381-78,841,439 (from NCBI)

This gene has 25 transcripts (splice variants), 201 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 or Ubiquitin-Specific Protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of Autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

USP36 Products (13)

mRNA	Protein	Name
NM_001321291.2	NP_001308220.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385169.1	NP_001372098.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 1
NM_001385170.1	NP_001372099.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385171.1	NP_001372100.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385172.1	NP_001372101.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385173.1	NP_001372102.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385174.1	NP_001372103.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385175.1	NP_001372104.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385176.1	NP_001372105.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385177.1	NP_001372106.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385178.1	NP_001372107.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385179.1	NP_001372108.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 4
NM_001385180.1	NP_001372109.1	ubiquitin carboxyl-terminal hydrolase 36 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	35989368	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	14715245	GOA
enables histone H2B deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	29274341	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	29274341	GOA
involved in negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	22622177	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	19208757	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	27445338	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	27445338	GOA
involved in regulation of rRNA processing	IDA IDA: Inferred from direct assay	19208757	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27445338	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19208757	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP36 Protein Structure

UCH

0
200
400
600
800
1000
1123 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 36	deubiquitinating enzyme 36

USP36 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USP36	Q9P275	DHX33	Homo sapiens	Q9H6R0	Anti Tag CoIP	19615732
Intra	USP36	Q9P275	DHX33	Homo sapiens	Q9H6R0	Anti Tag CoIP	33961781
Intra	USP36	Q9P275	DHX33	Homo sapiens	Q9H6R0	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15547	USP36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19043	Usp36 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25533	Usp36 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP36	VGNC	VGNC:52844
Felis catus	USP36	VGNC	VGNC:66882
Mus musculus	USP36	MGD	MGI:1919594
Canis familiaris	USP36	VGNC	VGNC:55014
Macaca mulatta	USP36	VGNC	VGNC:79219
Rattus norvegicus	USP36	RGD	RGD:1309937
Others	USP36	NCBI