DHX33 - DEAH-box helicase 33 Gene

Also Known as DDX33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56919

About DHX33

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,440,917-5,468,982 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 5.2), appendix (RPKM 3.8) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

DHX33 Products (2)

mRNA Protein Name
NM_001199699.2 NP_001186628.1 ATP-dependent RNA helicase DHX33 isoform 2
NM_020162.4 NP_064547.2 ATP-dependent RNA helicase DHX33 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
23871209 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
26100019 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
enables rDNA binding IDA
IDA: Inferred from direct assay
21930779 GOA
enables ribosomal large subunit binding IPI
IPI: Inferred from physical interaction
26100019 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
23871209 GOA
involved in positive regulation of transcription by RNA polymerase I IDA
IDA: Inferred from direct assay
21930779 GOA
Cellular Component GO Annotation Evidence References Source
part of NLRP3 inflammasome complex IDA
IDA: Inferred from direct assay
23871209 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23871209 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
21930779 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
21930779 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23871209 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX33 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (86 - 235)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (324 - 408)

HA2

HA2: Helicase associated domain (HA2) (471 - 563)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (598 - 697)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DHX33

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33

DHX33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DHX33 Q9H6R0 USP36 Homo sapiens Q9P275
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156418 KY386 99.86% Unkown
HY-184512 BCD38 / Unkown
HY-RS03752 DHX33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DHX33 MGD MGI:2445102
Felis catus DHX33 VGNC VGNC:61478
Macaca mulatta DHX33 VGNC VGNC:71633
Canis familiaris DHX33 VGNC VGNC:39943
Bos taurus DHX33 VGNC VGNC:54418
Rattus norvegicus DHX33 RGD RGD:1307239
Others DHX33 NCBI